TREATMENT OF PATIENTS WITH DISSEMINATED INTRAVASCULAR COAGULATION BY PROTEIN-C

被引：54

作者：

OKAJIMA, K

IMAMURA, H

KOGA, S

INOUE, M

TAKATSUKI, K

AOKI, N

机构：

[1] TOKYO MED & DENT UNIV,DEPT MED,TOKYO 113,JAPAN

[2] KUMAMOTO UNIV,SCH MED,DEPT MED,KUMAMOTO 860,JAPAN

[3] KUMAMOTO UNIV,SCH MED,DEPT BIOCHEM,KUMAMOTO 860,JAPAN

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 1990年 / 33卷 / 04期

关键词：

activated protein C; hypercoagulable state; thrombosis;

D O I：

10.1002/ajh.2830330413

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The therapeutic effect of highly purified protein C (PC) or activated protein C (APC) on three patients with disseminated intravascular coagulation (DIC) was tested. In two out of three cases, although therapeutic dose of heparin was not effective, PC or APC administration significantly improved the hypercoagulable state. In one case with acute leukemia who developed DIC with the severe gastrointestinal bleeding, APC corrected the hypercoagulable state without aggravating bleeding. These findings suggested that PC and/or APC might be effective in correcting hypercoagulable state without any adverse effect. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：277 / 278

页数：2