ANTIBODY TO SIGNAL RECOGNITION PARTICLE IN POLYMYOSITIS

被引：226

作者：

TARGOFF, IN

JOHNSON, AE

MILLER, FW

机构：

[1] UNIV OKLAHOMA,HLTH SCI CTR,DEPT MED,OKLAHOMA CITY,OK 73190

[2] VET ADM MED CTR,OKLAHOMA CITY,OK 73104

[3] UNIV OKLAHOMA,DEPT CHEM & BIOCHEM,NORMAN,OK 73019

[4] NIAMSD,BETHESDA,MD

来源：

ARTHRITIS AND RHEUMATISM | 1990年 / 33卷 / 09期

关键词：

D O I：

10.1002/art.1780330908

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Using immunoprecipitation, we identified 13 patients with antibodies to the signal recognition particle (SRP) from a collection of sera representing 265 poly‐myositis/dermatomyositis (PM/DM) patients. Antibody reactivity with SRP was confirmed by enzyme‐linked immunosorbent assay and immunoprecipitation with isolated dog pancreas SRP. The antibody was present in the serum of 4% of PM/DM patients, and 18% of PM/ DM patients with anticytoplasmic antibodies other than anti‐Jo‐1, but not in patients with other conditions who had anticytoplasmic antibodies. Anti‐SRP was associated with classic adult PM, and some of these cases were unusually severe and/or of rapid onset; it was not found in patients with overlap syndromes or with DM involvement. Unlike patients with antibodies to aminoacyl‐transfer RNA synthetases, patients with anti‐SRP had a low frequency of pulmonary fibrosis, as well as of arthritis and Raynaud's phenomenon. Anti‐SRP antibodies may serve as a marker for a second, distinct subgroup of adult PM. Copyright © 1990 American College of Rheumatology

引用

页码：1361 / 1370

页数：10

共 60 条

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