LARGE-SCALE FUNCTIONAL REORGANIZATION IN ADULT MONKEY CORTEX AFTER PERIPHERAL-NERVE INJURY

被引:132
作者
GARRAGHTY, PE
KAAS, JH
机构
[1] Department of Psychology, Vanderbilt University, Nashville
[2] Department of Psychology, 301 Wilson Hall, Vanderbilt University, Nashville
关键词
SOMATOSENSORY CORTEX; MEDIAN NERVE; ULNAR NERVE; CORTICAL PLASTICITY;
D O I
10.1073/pnas.88.16.6976
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
In adult monkeys, peripheral nerve injuries induce dramatic examples of neural plasticity in somatosensory cortex. It has been suggested that a cortical distance limit exists and that the amount of plasticity that is possible after injury is constrained by this limit. We have investigated this possibility by depriving a relatively large expanse of cortex by transecting and ligating both the median and the ulnar nerves to the hand. Electrophysiological recording in cortical areas 3b and 1 in three adult squirrel monkeys no less than 2 months after nerve transection has revealed that cutaneous responsiveness is regained throughout the deprived cortex and that a roughly normal topographic order is reestablished for the reorganized cortex.
引用
收藏
页码:6976 / 6980
页数:5
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