DOPAMINE AGONISTS POTENTIATE ANTIAKINETIC EFFECTS OF COMPETITIVE NMDA-ANTAGONISTS IN MONOAMINE-DEPLETED MICE

被引：35

作者：

KANNARI, K ^{[1
]}

MARKSTEIN, R ^{[1
]}

机构：

[1] SANDOZ PHARMA,PRECLIN RES,CH-4002 BASEL,SWITZERLAND

来源：

JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION | 1991年 / 84卷 / 03期

关键词：

COMPETITIVE NMDA-ANTAGONISTS (SDZ EAA-494; CGP; 37849); DOPAMINE AGONISTS (CI 201-678; SDZ; 205-152); GLUTAMATE; DOPAMINE; LOCOMOTION; MOUSE;

D O I：

10.1007/BF01244971

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The competitive NMDA-antagonists SDZ EAA-494 and CGP 37849 and the mixed D-1/D-2 dopamine agonists CI 201-678 and SDZ 205-152 reverse akinesia in monoamine-depleted mice in a dose dependent manner. Combination of threshold doses of NMDA-antagonists with dopamine agonists markedly enhances anti-akinetic effects. CI 201-678 which in addition to D-1 and D-2 receptors stimulates alpha-2 receptors produces a stronger effect than SDZ 205-152 which is devoid of alpha-2 agonist activity. The results indicate that concomitant blockade of NMDA-receptors and activation of dopamine receptors results in synergistic or at least additive motor stimulatory effects.

引用

页码：211 / 220

页数：10

共 20 条

[1] SYNTHESIS AND NMDA ANTAGONISTIC PROPERTIES OF THE ENANTIOMERS OF 4-(3-PHOSPHONOPROPYL)PIPERAZINE-2-CARBOXYLIC ACID (CPP) AND OF THE UNSATURATED ANALOG (E)-4-(3-PHOSPHONOPROP-2-ENYL)PIPERAZINE-2-CARBOXYLIC ACID (CPP-ENE) [J].