PROTEIN GLYCATION - EFFECTS UPON PROTEIN RECOGNITION BY THE PROXIMAL TUBULE

被引：11

作者：

KOWLURU, A

KOWLURU, RA

SOLOMON, S

MARTINEZ, L

机构：

[1] UNIV CALIF LOS ALAMOS SCI LAB,DIV LIFE SCI,LOS ALAMOS,NM 87545

[2] UNIV NEW MEXICO,SCH MED,DEPT PHYSIOL,ALBUQUERQUE,NM 87131

来源：

LIFE SCIENCES | 1992年 / 50卷 / 04期

关键词：

D O I：

10.1016/0024-3205(92)90335-M

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Reabsorption of I-125 labeled unmodified and glycated albumin by the proximal tubule was studied using micropuncture technique in wistar rats of different ages. The data show a significant reabsorption of unmodified albumin while the glycated albumin was virtually excluded from reabsorption process. Among different explanations considered, we think molecular charge of the protein seems to be a key factor for the altered recognition of glycated albumin by the proximal tubule.

引用

页码：281 / 286

页数：6

共 15 条

[1]

BITENSKY MW, 1986, ENDOCRINE SOC P, V106, pA301

[2]

BITENSKY MW, 1989, MAILLARD REACTION AG, P185

[3] PROTEIN HANDLING BY RENAL TUBULE [J].