NEW DELTA(8(14))-3-BETA,7-ALPHA-DIHYDROXYSTEROLS FROM THE MARINE SPONGE PELLINA-SEMITUBULOSA

被引：27

作者：

NOTARO, G

PICCIALLI, V

SICA, D

PRONZATO, R

机构：

[1] NAPLES UNIV,DIPARTIMENTO CHIM ORGAN & BIOL,VIA MEZZOCANNONE 16,I-80134 NAPLES,ITALY

[2] UNIV GENOA,IST ZOOL,I-16126 GENOA,ITALY

来源：

JOURNAL OF NATURAL PRODUCTS | 1992年 / 55卷 / 06期

关键词：

D O I：

10.1021/np50084a011

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The marine sponge Pellina semitubulosa was examined for polyoxygenated sterols. The sponge contained six new 3-beta,7-alpha-diols, (22E)-5-alpha-cholesta-8(14),22-diene-3-beta,7-alpha-diol {2}, (22E,24R)-24-methyl-5-alpha-cholesta-8(14),22-diene-3-beta,7-alpha-diol {3}, (22E,24S)-24-methyl-5-alpha-cholesta-8(14),22-diene-3-beta,7-alpha-diol {4}, 24-methyl-5-alpha-cholesta-8(14),24(28)-diene-3-beta, 7-alpha-diol {5}, (24Z)-24-ethyl-5-alpha-cholesta-8(14),24(28)-diene-3-beta,7-alpha-diol {6}, and (24E)-24-ethyl-5-alpha-cholesta-8(14),24(28)-diene-3-beta,7-alpha-diol {7}, along with the previously synthesized 5-alpha-cholest-8(14)-ene-3-beta,7-alpha-diol {1}. The structure of the new natural products was determined by interpretation of spectral data and secured by synthesis of 1 starting from 5-alpha-cholest-7-en-3-beta-ol.

引用

页码：773 / 779

页数：7

共 17 条

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