HYPOTENSIVE AND ANTINOCICEPTIVE EFFECTS OF ETHER-LINKED AND RELATIVELY NON-PUNGENT ANALOGS OF N-NONANOYL VANILLYLAMIDE

被引:43
作者
CHEN, IJ [1 ]
YANG, JM [1 ]
YEH, JL [1 ]
WU, BN [1 ]
LO, YC [1 ]
CHEN, SJ [1 ]
机构
[1] CHIA NAN COLL PHARM,DEPT PHARM,TAINAN 71710,TAIWAN
关键词
CAPSAICIN; HYPOTENSIVE ACTIVITY; ANTINOCICEPTIVE ACTIVITY; NON-PUNGENT ANALOGS;
D O I
10.1016/0223-5234(92)90002-I
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
N-nonanoyl vanillylamide (1) is a synthetic substitute of capsaicin (2), a pungent principle in red pepper. 1 was reacted with succinic anhydride, 3-chloro-1,2-propanediol, sodium chloroacetate, and 2-chloroethanol to furnish N-nonanoyl vanillylamide-4-succinyl ester (3), N-nonanoyl vanillylamide-4-glyceryl ether (4), sodium N-nonanoyl vanillylamide-4-0-acetate (5) and N-nonanoyl vanillylamide-4-glycol ether (6), respectively. A 3,4-methylenedioxy derivative of 1, N-nonanoyl piperonylamide (7), was synthesized from piperonylamine HCl and nonanoyl chloride. The ether analogues 4-6 all demonstrated marked antinociceptive and hypotensive effects without producing any overt irritation. In addition, these compounds revealed no untoward vagus reflex or transient hypertensive effect as previously found in 1 or 2.
引用
收藏
页码:187 / 192
页数:6
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