COMPARATIVE-STUDY OF SELECTED COUPLING REAGENTS IN DIPEPTIDE SYNTHESIS

被引:59
作者
DUDASH, J [1 ]
JIANG, JJ [1 ]
MAYER, SC [1 ]
JOULLIE, MM [1 ]
机构
[1] UNIV PENN,DEPT CHEM,PHILADELPHIA,PA 19104
关键词
D O I
10.1080/00397919308009787
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A comparative study of the effectiveness of selected coupling reagents in dipeptide synthesis was conducted. Included in the study were a new coupling reagent, pentafluorophenyl diphenylphosphinate (FDPP, 1), benzotriazol-1-yl-oxytris(dimethylamino)phosphonium hexafluorophosphate (BOP, 2), 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU, 3), and isobutyl chloroformate (IBCF, 4). We found the BOP (2) afforded the highest yields and lowest limits of racemization.
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页码:349 / 356
页数:8
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