FATE OF PATIENTS WITH RESIDUAL TUMOR AT THE BRONCHIAL RESECTION MARGIN

被引：40

作者：

GEBITEKIN, C

GUPTA, NK

SATUR, CMR

OLGAC, G

MARTIN, PG

SAUNDERS, NR

WALKER, DR

机构：

[1] Department. Of Cardiothoracic Surgery, Killingbeck Hospital, Leeds, LS14 6UQ, York Road

来源：

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY | 1994年 / 8卷 / 07期

关键词：

RESECTION MARGIN; RESIDUAL TUMOR; NONSMALL CELL LUNG CARCINOMA;

D O I：

10.1016/1010-7940(94)90025-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The presence of microscopic deposits of tumour cells at the bronchial resection margin (BRM) may adversely affect the prognosis of patients. Residual tumour cells were identified at the BRM in 40 (5.4%) of 735 patients who had been operated on for non-small cell lung carcinoma (NSCLC). The extent of disease was stage I in 7 (17.5%), stage II in 21 (52.5%), stage III a in 10 (25 %) and stage III b in 2 (5%) patients. Malignant cells were found to have infiltrated the submucosal lymphatics in 5 (12.5%) cases and the peribronchial tissue in the remaining 35 (87.5%). Fifteen (37.5%) patients received adjuvant radiotherapy (RT). Recurrence of the disease was diagnosed in 29 (72.5%) patients after a median of 17 months (range 3-111). The recurrence was local in 17 (59%) and distant in 12 (41%). The 5-year overall actuarial survival rate was 21.6% and was not affected by RT (P = NS). Only patients with stage III a disease and a positive bronchial stump had a significantly reduced 5-year survival rate compared to those with a negative stump, 0% vs 17% (P<0.001). Tumour cells at the resection margin did not affect the survival in this cohort except those with stage III a disease, and the addition of adjuvant RT did not significantly affect its recurrence in patients with NSCLC.

引用

页码：339 / 344

页数：6

共 12 条

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