REDUCTION OF BACTERIURIA AND PYURIA AFTER INGESTION OF CRANBERRY JUICE

Objective.-To determine the effect of regular intake of cranberry juice beverage on bacteriuria and pyuria in elderly women. Design.-Randomized, double-blind, placebo-controlled trial. Subjects.-Volunteer sample of 153 elderly women (mean age, 78.5 years). Intervention.-Subjects were randomly assigned to consume 300 mt per day of a commercially available standard cranberry beverage or a specially prepared synthetic placebo drink that was indistinguishable in taste, appearance, and vitamin C content but lacked cranberry content. Outcome Measures.-A baseline urine sample and six clean-voided study urine samples were collected at approximately 1-month intervals and tested quantitatively for bacteriuria and the presence of white blood cells. Results.-Subjects randomized to the cranberry beverage had odds of bacteriuria (defined as organisms numbering greater than or equal to 10(5)/mL) with pyuria that were only 42% of the odds in the control group (P=.004). Their odds of remaining bacteriuric-pyuric, given that they were bacteriuric-pyuric in the previous month, were only 27% of the odds in the control group (P=.006). Conclusions.-These findings suggest that use of a cranberry beverage reduces the frequency of bacteriuria with pyuria in older women. Prevalent beliefs about the effects of cranberry juice on the urinary tract may have microbiologic justification.