A HIGH-DENSITY OF MUSCARINIC RECEPTORS IN THE ROSTRAL VENTROLATERAL MEDULLA OF THE RAT IS REVEALED BY CORRECTION FOR AUTORADIOGRAPHIC EFFICIENCY

被引：45

作者：

ERNSBERGER, P ^{[1
]}

ARANGO, V ^{[1
]}

REIS, DJ ^{[1
]}

机构：

[1] CORNELL UNIV, MED CTR, COLL MED, HYPERTENS LAB, 411 E 69TH ST, NEW YORK, NY 10021 USA

来源：

NEUROSCIENCE LETTERS | 1988年 / 85卷 / 02期

关键词：

D O I：

10.1016/0304-3940(88)90348-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous reports of a low density of muscarinic receptors in the vicinity of the rostral ventrolateral reticular nucleus (RVL) conflict with the presence of a musarinic cholinergic mechanism regulating arterial pressure, and may reflect low autoradiographic efficiency due to quenching of tritium emissions by white matter. Regional autoradiographic efficiency was determined using brains uniformly labeled with O-[3H]methylglucose. Within the RVL, autoradiographic efficiency was only 50 .+-. 2% relative to gray matter. The uncorrected density of muscarinic receptors (M2) labeled by [3H]quinuclidinyl benzilate in the RVL appeared to be low relative to cranial nerve nuclei, but the corrected muscarinic receptor density approximated that within the nucleus tractus solitarii. We conclude that a high density of M2 muscarinic acetylcholine receptors is present in the RVL.

引用

页码：179 / 186

页数：8

共 20 条

[1] NEURONS OF C1 AREA MEDIATE CARDIOVASCULAR-RESPONSES INITIATED FROM VENTRAL MEDULLARY SURFACE
BENARROCH, EE
GRANATA, AR
RUGGIERO, DA
PARK, DH
REIS, DJ
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1986, 250 (05): : R932 - R945
[2] CHARACTER OF THE MUSCARINIC RECEPTORS IN DIFFERENT REGIONS OF THE RAT-BRAIN
BIRDSALL, NJM
HULME, EC
BURGEN, A
[J]. PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1980, 207 (1166): : 1 - 12
[3] GEARY WA, 1983, J PHARMACOL EXP THER, V225, P234
[4] GIULIANO R, 1987, Society for Neuroscience Abstracts, V13, P808
[5] GIULIANO R, 1986, SOC NEUR ABSTR, V12, P963
[6] AUTORADIOGRAPHIC DETERMINATION OF REGIONAL BRAIN GLUCOSE CONTENT
GJEDDE, A
DIEMER, NH
[J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1983, 3 (03) : 303 - 310
[7] QUANTITATIVE RECEPTOR AUTORADIOGRAPHY - TISSUE DEFATTING ELIMINATES DIFFERENTIAL SELF-ABSORPTION OF TRITIUM RADIATION IN GRAY AND WHITE MATTER OF BRAIN
HERKENHAM, M
SOKOLOFF, L
[J]. BRAIN RESEARCH, 1984, 321 (02) : 363 - 368
[8] GLOBAL INCREASE IN CEREBRAL METABOLISM AND BLOOD-FLOW PRODUCED BY FOCAL ELECTRICAL-STIMULATION OF DORSAL MEDULLARY RETICULAR-FORMATION IN RAT
IADECOLA, C
NAKAI, M
MRAOVITCH, S
RUGGIERO, DA
TUCKER, LW
REIS, DJ
[J]. BRAIN RESEARCH, 1983, 272 (01) : 101 - 114
[9] QUANTITATIVE RECEPTOR MAPPING BY AUTORADIOGRAPHY - SOME CURRENT TECHNICAL PROBLEMS
KUHAR, MJ
UNNERSTALL, JR
[J]. TRENDS IN NEUROSCIENCES, 1985, 8 (02) : 49 - 53
[10] PHENYLETHANOLAMINE N-METHYLTRANSFERASE-CONTAINING NEURONS IN THE ROSTRAL VENTROLATERAL MEDULLA OF THE RAT .1. NORMAL ULTRASTRUCTURE
MILNER, TA
PICKEL, VM
PARK, DH
JOH, TH
REIS, DJ
[J]. BRAIN RESEARCH, 1987, 411 (01) : 28 - 45

← 1 2 →