LIPOSOME-ASSOCIATED RETINOIC ACID - INCREASED INVITRO ANTIPROLIFERATIVE EFFECTS ON NEOPLASTIC-CELLS

被引：26

作者：

NASTRUZZI, C

WALDE, P

MENEGATTI, E

GAMBARI, R

机构：

[1] SWISS FED INST TECHNOL,INST POLYMERE,CH-8092 ZURICH,SWITZERLAND

[2] UNIV FERRARA,DEPT PHARMACEUT SCI,I-44100 FERRARA,ITALY

[3] UNIV FERRARA,DEPT BIOCHEM,I-44100 FERRARA,ITALY

来源：

FEBS LETTERS | 1990年 / 259卷 / 02期

关键词：

Liposome; Retinoic acid; Tumor cell growth; Vesicle;

D O I：

10.1016/0014-5793(90)80030-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The activity of liposome-associated retinoic acid was analyzed on in vitro cultured tumor cell lines and compared to the antiproliferative effects of free retinoic acid. It was found that liposome-associated retinoic acid is about 300 times more active than free retinoic acid in inhibiting in vitro cell growth of leukemic and melanoma cell lines. An increased activity of retinoic acid (10-20 times) was also obtained after premixing of this compound with empty liposomes, demonstrating that the retinoic acid efficiently interacts with liposomes which may facilitate solubility and cell uptake of retinoids. © 1990.

引用

页码：293 / 296

页数：4

共 17 条

[1]

Alving CR., 1987, LIPOSOMES BIOPHYSICS, P195

[2]

[Anonymous], 1988, LIPOSOMES DRUG CARRI

[3] INVIVO UPTAKE OF CHYLOMICRON (H-3)-LABELED RETINYL ESTER BY RAT-LIVER - EVIDENCE FOR RETINOL TRANSFER FROM PARENCHYMAL TO NON-PARENCHYMAL CELLS [J].