INVESTIGATIONS OF A MANGANESE-CONTAINING MIMIC OF SUPEROXIDE-DISMUTASE IN RIBOFLAVIN PHOTOTOXICITY IN HUMAN-CELLS INVITRO

被引：5

作者：

ORTEL, B ^{[1
]}

GANGE, RW ^{[1
]}

HASAN, T ^{[1
]}

机构：

[1] HARVARD UNIV, MASSACHUSETTS GEN HOSP,SCH MED,DEPT DERMATOL, WELLMAN LABS PHOTOMED,50 BLOSSOM ST, BOSTON, MA 02114 USA

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 1990年 / 7卷 / 2-4期

关键词：

manganese desferioxamine; phototoxicity; Riboflavin; SOD mimic; superoxide anion;

D O I：

10.1016/1011-1344(90)85161-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The activity and specificity of a manganese-containing low molecular weight mimic of superoxide dismutase (manganese desferioxamine (Mndf)) were investigated in riboflavin (Rf) photosensitization in solution and cell culture. In addition to the very high superoxide dismutase-like activity of Mndf at micromolar concentrations, photochemical studies in solution indicated that it could quench excited singlet and triplet states at millimolar concentrations. Human erythrocytes, human lymphocytes and a human bladder carcinoma cell line were used to evaluate the potential of Mndf for in vivo use. The efficacy and toxicity of Mndf in the protection against Rf photoxicity varied between the different cell types. © 1990.

引用

页码：261 / 276

页数：16

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