CHROMATOGRAPHIC RESOLUTION OF THE CHIRAL ISOMERS OF SEVERAL BETA-BLOCKERS OVER CELLULOSE TRIS(3,5-DIMETHYLPHENYLCARBAMATE) CHIRAL STATIONARY PHASE

被引:31
作者
CHING, CB
LIM, BG
LEE, EJD
NG, SC
机构
[1] NATL UNIV SINGAPORE,DEPT PHARMACOL,SINGAPORE 0511,SINGAPORE
[2] NATL UNIV SINGAPORE,DEPT CHEM,SINGAPORE 0511,SINGAPORE
关键词
CHIRAL RESOLUTION; BETA-BLOCKERS; HPLC; CELLULOSE TRIS(3,5-DIMETHYLPHENYLCARBAMATE) CHIRAL STATIONARY PHASE;
D O I
10.1002/chir.530040308
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The optical resolution of seven beta-blockers which have in common the N-isopropyl-3-aryloxy-2-hydroxypropylamine moiety was carried out by HPLC using the cellulose tris(3,5-dimethylphenylcarbamate) chiral stationary phase to quantitatively characterize the enantioselectivity of these compounds, The capacity factors and separation factors at different column temperature were determined with some qualitative trends derived. A compensation effect was observed for these compounds where there exists an approximately linear relationship between the enantiomeric differences in enthalpic and entropic energies.
引用
收藏
页码:174 / 177
页数:4
相关论文
共 9 条
  • [1] THE COMPENSATION EFFECT IN HETEROGENEOUS CATALYSIS
    CREMER, E
    [J]. ADVANCES IN CATALYSIS, 1955, 7 : 75 - 91
  • [2] CHROMATOGRAPHIC RESOLUTION OF RACEMATES ON CHIRAL STATIONARY PHASES .1. INFLUENCE OF THE SUPRAMOLECULAR STRUCTURE OF CELLULOSE TRIACETATE
    FRANCOTTE, E
    WOLF, RM
    LOHMANN, D
    MUELLER, R
    [J]. JOURNAL OF CHROMATOGRAPHY, 1985, 347 (01): : 25 - 37
  • [3] SIMULTANEOUS DETERMINATION OF (R)-CELIPROLOL AND (S)-CELIPROLOL IN HUMAN-PLASMA AND URINE - HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ASSAY ON A CHIRAL STATIONARY PHASE WITH FLUORIMETRIC DETECTION
    HARTMANN, C
    KRAUSS, D
    SPAHN, H
    MUTSCHLER, E
    [J]. JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1989, 496 (02): : 387 - 396
  • [4] Hesse G., 1973, CHROMATOGRAPHIA, V6, P277
  • [5] LIQUID-CHROMATOGRAPHY ON TRIACETYLCELLULOSE .7. HIGH-PRESSURE LIQUID-CHROMATOGRAPHY ON TRIACETYLCELLULOSE - CHARACTERIZATION OF A SORBENT FOR THE SEPARATION OF ENANTIOMERS
    KOLLER, H
    RIMBOCK, KH
    MANNSCHRECK, A
    [J]. JOURNAL OF CHROMATOGRAPHY, 1983, 282 (DEC): : 89 - 94
  • [6] CHIRALITY - CLINICAL PHARMACOKINETIC AND PHARMACODYNAMIC CONSIDERATIONS
    LEE, EJD
    WILLIAMS, KM
    [J]. CLINICAL PHARMACOKINETICS, 1990, 18 (05) : 339 - 345
  • [7] CHROMATOGRAPHIC RESOLUTION .12. OPTICAL RESOLUTION OF BETA-BLOCKERS BY HPLC ON CELLULOSE TRIPHENYLCARBAMATE DERIVATIVES
    OKAMOTO, Y
    KAWASHIMA, M
    ABURATANI, R
    HATADA, K
    NISHIYAMA, T
    MASUDA, M
    [J]. CHEMISTRY LETTERS, 1986, (07) : 1237 - 1240
  • [8] PRINCHARD BNC, 1980, HDB EXPT PHARM 2, V54, P559
  • [9] RAPID HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR THE MEASUREMENT OF THE ENANTIOMERS OF METOPROLOL IN SERUM USING A CHIRAL STATIONARY PHASE
    RUTLEDGE, DR
    GARRICK, C
    [J]. JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1989, 497 : 181 - 190