ENHANCED SENSITIVITY TO OXIDATIVE STRESS IN CU,ZNSOD DEPLETED RAT ERYTHROCYTES

被引：10

作者：

BARTOLI, GM ^{[1
]}

PALOZZA, P ^{[1
]}

PICCIONI, E ^{[1
]}

机构：

[1] UNIV TOR VERGATA, DEPT BIOL, ROME, ITALY

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1123卷 / 03期

关键词：

LIPID PEROXIDATION; SUPEROXIDE DISMUTASE; COPPER; OXIDATIVE STRESS; (RAT ERYTHROCYTE);

D O I：

10.1016/0005-2760(92)90009-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects on red blood cells of superoxide dismutase (Cu,ZnSOD) depletion, induced by feeding Wistar rats with a copper deficient diet, were investigated. SOD depleted red blood cells were more sensitive to peroxidation and to hemolysis than normal cells when exposed to tert-butylhydroperoxide (t-BOOH). Membranes isolated from SOD depleted cells showed a lower content of vitamin E and higher (Na+, K+) and Mg2+ ATPase activities. These results support the view that superoxide dismutase plays an important role in cellular oxidative metabolism.

引用

收藏

页码：291 / 295

页数：5

相关论文

共 38 条

[1] STUDIES ON LIPID-PEROXIDATION IN RAT-LIVER BY COPPER DEFICIENCY [J].

BALEVSKA, PS ;

RUSSANOV, EM ;

KASSABOVA, TA .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY, 1981, 13 (04) :489-493

[2] SUPEROXIDE-DISMUTASE DEPLETION AND LIPID-PEROXIDATION IN RAT-LIVER MICROSOMAL-MEMBRANES - CORRELATION WITH LIVER CARCINOGENESIS [J].

BARTOLI, GM ;

GIANNATTASIO, B ;

PALOZZA, P ;

CITTADINI, A .

BIOCHIMICA ET BIOPHYSICA ACTA, 1988, 966 (02) :214-221

[3] A METHEMOGLOBIN-DEPENDENT AND PLASMA-STIMULATED EXPERIMENTAL-MODEL OF OXIDATIVE HEMOLYSIS [J].

BENATTI, U ;

MORELLI, A ;

DAMIANI, G ;

DEFLORA, A .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1982, 106 (04) :1183-1190

[4] SUPEROXIDE-DEPENDENT LIPID-PEROXIDATION AND VITAMIN-E CONTENT OF MICROSOMES FROM HEPATOMAS WITH DIFFERENT GROWTH-RATES [J].

BORRELLO, S ;

MINOTTI, G ;

PALOMBINI, G ;

GRATTAGLIANO, A ;

GALEOTTI, T .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1985, 238 (02) :588-595

[5] IMPAIRMENT OF MICROSOMAL CALCIUM SEQUESTRATION ACTIVITY UPON SUPEROXIDE-DISMUTASE DEPLETION IN RAT-LIVER [J].

CALVIELLO, G ;

PALOZZA, P ;

BOSSI, D ;

PICCIONI, E ;

CITTADINI, A ;

BARTOLI, GM .

BIOCHIMICA ET BIOPHYSICA ACTA, 1988, 964 (02) :289-292

[6] PROOXIDANT STATES AND TUMOR PROMOTION [J].

CERUTTI, PA .

SCIENCE, 1985, 227 (4685) :375-381

[7]

Chiu D, 1982, FREE RADICAL BIO MED, V5, P115

[8] UNCOUPLING OF OXIDATIVE LEAK FORMATION FROM LIPID-PEROXIDATION IN THE HUMAN-ERYTHROCYTE MEMBRANE BY ANTIOXIDANTS AND DESFERRIOXAMINE [J].

DEUTICKE, B ;

LUTKEMEIER, P ;

SISTEMICH, M .

BIOCHIMICA ET BIOPHYSICA ACTA, 1987, 899 (01) :125-128

[9] PROGRESSIVE OXIDATIVE MEMBRANE DAMAGE IN ERYTHROCYTES AFTER PULSE TREATMENT WITH TERT-BUTYLHYDROPEROXIDE [J].

DEUTICKE, B ;

HELLER, KB ;

HAEST, CWM .

BIOCHIMICA ET BIOPHYSICA ACTA, 1987, 899 (01) :113-124

[10] LEAK FORMATION IN HUMAN-ERYTHROCYTES BY THE RADICAL-FORMING OXIDANT TERT-BUTYLHYDROPEROXIDE [J].

DEUTICKE, B ;

HELLER, KB ;

HAEST, CWM .

BIOCHIMICA ET BIOPHYSICA ACTA, 1986, 854 (02) :169-183

← 1 2 3 4 →