IDENTIFICATION OF A CANDIDATE GENE RESPONSIBLE FOR THE HIGH BLOOD-PRESSURE OF SPONTANEOUSLY HYPERTENSIVE RATS

被引:75
作者
IWAI, N [1 ]
INAGAMI, T [1 ]
机构
[1] VANDERBILT UNIV, MED CTR, SCH MED, DEPT BIOCHEM, NASHVILLE, TN 37232 USA
关键词
SA GENE; SPONTANEOUSLY HYPERTENSIVE RAT;
D O I
10.1097/00004872-199210000-00007
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Objective: We have recently isolated a gene, designated as the SA gene, which is more than 10 times more abundantly expressed in the kidneys of spontaneously hypertensive rats (SHR) than in those of Wistar-Kyoto (WKY) rats. To address the issue whether the SA gene is one of the genes responsible for the hypertension of SHR, a genetic cosegregation analysis of the blood pressure values with the genotypes in an F2 rat population was undertaken in this study. Methods and design: Male F2 rats were bred from SHR and WKY rats. The genotypes of the SA gene of the F2 rats were determined by utilizing the Stu I restriction fragment length polymorphism of the SA gene between SHR and WKY rats. The blood pressure values were determined by the tail-cuff method. The effect of the genotype of the SA gene on the blood pressure of the F2 rats was analysed by one-way analysis of variance. Results and conclusion: The blood pressure of the F2 rats inheriting two SHR alleles of the SA gene was significantly higher than that of the F2 rats inheriting two WKY alleles. This indicates that the SA gene, or a gene closely linked to it, has a capacity to influence the blood pressure values of the F2 rat population. Further studies to identify functions of the SA gene products will be necessary.
引用
收藏
页码:1155 / 1157
页数:3
相关论文
共 14 条
  • [1] INFLUENCE OF GENETIC BACKGROUND ON EXPRESSION OF OBESE (OB) GENE IN MOUSE
    COLEMAN, DL
    HUMMEL, KP
    [J]. DIABETOLOGIA, 1973, 9 (04) : 287 - 293
  • [2] RENAL-FUNCTION CURVE - A KEY TO UNDERSTANDING THE PATHOGENESIS OF HYPERTENSION
    GUYTON, AC
    [J]. HYPERTENSION, 1987, 10 (01) : 1 - 6
  • [3] Guyton AC, 1990, HYPERTENSION PATHOPH, P1029
  • [4] CHROMOSOMAL MAPPING OF 2 GENETIC-LOCI ASSOCIATED WITH BLOOD-PRESSURE REGULATION IN HEREDITARY HYPERTENSIVE RATS
    HILBERT, P
    LINDPAINTNER, K
    BECKMANN, JS
    SERIKAWA, T
    SOUBRIER, F
    DUBAY, C
    CARTWRIGHT, P
    DEGOUYON, B
    JULIER, C
    TAKAHASI, S
    VINCENT, M
    GANTEN, D
    GEORGES, M
    LATHROP, GM
    [J]. NATURE, 1991, 353 (6344) : 521 - 529
  • [5] ISOLATION OF PREFERENTIALLY EXPRESSED GENES IN THE KIDNEYS OF HYPERTENSIVE RATS
    IWAI, N
    INAGAMI, T
    [J]. HYPERTENSION, 1991, 17 (02) : 161 - 169
  • [6] KAWABE K, 1978, JPN HEART J, V19, P886
  • [7] MOLECULAR EVIDENCE OF GENETIC-HETEROGENEITY IN WISTAR-KYOTO RATS - IMPLICATIONS FOR RESEARCH WITH THE SPONTANEOUSLY HYPERTENSIVE RAT
    KURTZ, TW
    MONTANO, M
    CHAN, L
    KABRA, P
    [J]. HYPERTENSION, 1989, 13 (02) : 188 - 192
  • [8] COSEGREGATION OF THE RENIN ALLELE OF THE SPONTANEOUSLY HYPERTENSIVE RAT WITH AN INCREASE IN BLOOD-PRESSURE
    KURTZ, TW
    SIMONET, L
    KABRA, PM
    WOLFE, S
    CHAN, L
    HJELLE, BL
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1990, 85 (04) : 1328 - 1332
  • [9] STRUCTURAL ALTERATIONS OF THE RENIN GENE IN STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS - EXAMINATION OF GENOTYPE-PHENOTYPE CORRELATIONS
    LINDPAINTNER, K
    TAKAHASHI, S
    GANTEN, D
    [J]. JOURNAL OF HYPERTENSION, 1990, 8 (08) : 763 - 773
  • [10] GENETIC-HETEROGENEITY OF THE SPONTANEOUSLY HYPERTENSIVE RAT
    NABIKA, T
    NARA, Y
    IKEDA, K
    ENDO, J
    YAMORI, Y
    [J]. HYPERTENSION, 1991, 18 (01) : 12 - 16