UPDATE ON PROLIFERATION-ASSOCIATED ANTIBODIES APPLICABLE TO FORMALIN-FIXED PARAFFIN-EMBEDDED TISSUE AND THEIR CLINICAL-APPLICATIONS

被引：16

作者：

YU, CCW

FILIPE, MI

机构：

来源：

HISTOCHEMICAL JOURNAL | 1993年 / 25卷 / 12期

关键词：

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This review provides an update on proliferation-associated antibodies applicable to immunohistochemical techniques in formalin-fixed paraffin-embedded tissue. New insights into proliferating cell nuclear antigen (PCNA) and antibodies to PCNA are presented. The characterization of the protein recognized by the Ki-67 antibody has enabled production of a new range of antibodies (monoclonal and polyclonal) which have immunostaining profiles similar to those of the original antibody. A new proliferation-associated antibody, KiS1, is described. The clinical applications of antibodies to PCNA in human material are summarized, and the limitations of these studies are discussed.

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页码：843 / 853

页数：11

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