NEUROFIBROMATOSIS-1 MESSENGER-RNA EXPRESSION IN BLOOD-VESSELS

被引:15
作者
AHLGRENBECKENDORF, JA
MAGGIO, WW
CHEN, F
KENT, TA
机构
[1] UNIV TEXAS,MED BRANCH,DEPT NEUROL,GALVESTON,TX 77555
[2] UNIV TEXAS,MED BRANCH,DEPT SURG,DIV NEUROSURG,GALVESTON,TX 77555
[3] UNIV TEXAS,MED BRANCH,DEPT PSYCHIAT,GALVESTON,TX 77555
[4] UNIV TEXAS,MED BRANCH,DEPT PHARMACOL,GALVESTON,TX 77555
关键词
D O I
10.1006/bbrc.1993.2580
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Vascular hypertrophic lesions occur in neurofibromatosis type 1 (NF1). The role of the gene which causes NF1 in the growth and development of blood vessels is not known. mRNA expression of the NF1 gene was studied in blood vessels in the transition between intact and culture and in quiescent and proliferative conditions. The expression and alternative splicing pattern of the catalytic domain of NF1 consistently changed in proliferating cells, supporting a role for this gene in the regulation of growth of vascular smooth muscle and the vascular pathology in NF1. © 1993 Academic Press, Inc.
引用
收藏
页码:1019 / 1024
页数:6
相关论文
共 16 条
[1]   A CONSERVED ALTERNATIVE SPLICE IN THE VONRECKLINGHAUSEN NEUROFIBROMATOSIS (NF1) GENE PRODUCES 2 NEUROFIBROMIN ISOFORMS, BOTH OF WHICH HAVE GTPASE-ACTIVATING PROTEIN-ACTIVITY [J].
ANDERSEN, LB ;
BALLESTER, R ;
MARCHUK, DA ;
CHANG, E ;
GUTMANN, DH ;
SAULINO, AM ;
CAMONIS, J ;
WIGLER, M ;
COLLINS, FS .
MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (01) :487-495
[2]   IDENTIFICATION AND CHARACTERIZATION OF THE NEUROFIBROMATOSIS TYPE-1 PROTEIN PRODUCT [J].
DECLUE, JE ;
COHEN, BD ;
LOWY, DR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (22) :9914-9918
[3]   SEROTONIN-INDUCED DEOXYRIBONUCLEIC-ACID SYNTHESIS IN VASCULAR SMOOTH-MUSCLE CELLS INVOLVES A NOVEL, PERTUSSIS TOXIN-SENSITIVE PATHWAY [J].
KAVANAUGH, WM ;
WILLIAMS, LT ;
IVES, HE ;
COUGHLIN, SR .
MOLECULAR ENDOCRINOLOGY, 1988, 2 (07) :599-605
[4]   IDENTIFICATION OF A MAJOR GTP-BINDING PROTEIN IN BOVINE AORTIC SMOOTH-MUSCLE MEMBRANES AS SMG-P21, A GTP-BINDING PROTEIN HAVING THE SAME EFFECTOR DOMAIN AS RAS-P21S [J].
KAWATA, M ;
KAWAHARA, Y ;
ARAKI, S ;
SUNAKO, M ;
TSUDA, T ;
FUKUZAKI, H ;
MIZOGUCHI, A ;
TAKAI, Y .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 163 (03) :1418-1427
[5]   CALCIUM CHANNELS AND NIFEDIPINE INHIBITION OF SEROTONIN-INDUCED [H-3] THYMIDINE INCORPORATION IN CULTURED CEREBRAL SMOOTH-MUSCLE CELLS [J].
KENT, TA ;
JAZAYERI, A ;
SIMARD, JM .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1992, 12 (01) :139-146
[6]   DIFFERENTIAL CONTRIBUTION OF M(R) 120 KDA RASGTPASE-ACTIVATING PROTEIN AND NEUROFIBROMATOSIS TYPE-1 GENE-PRODUCT DURING THE TRANSITION FROM GROWTH-PHASE TO ARRESTED STATE IN HUMAN FIBROBLASTS ACCOMPANIED BY A UNIQUE RASGTPASE-ACTIVATING ACTIVITY [J].
KOBAYASHI, M ;
HASHIMOTO, N ;
HOSHINO, M ;
HATTORI, S ;
IWASHITA, S .
FEBS LETTERS, 1993, 327 (02) :177-182
[7]  
KYRITSIS AP, 1992, INT J ONCOL, V1, P149
[8]  
LEDOURAIN NM, 1986, NEUROFIBROMATOSIS, V486, P67
[9]   ALTERNATIVE SPLICING OF NEUROFIBROMATOSIS TYPE-1 GENE TRANSCRIPT IN MALIGNANT BRAIN-TUMORS - PCR ANALYSIS OF FROZEN-SECTION MESSENGER-RNA [J].
MOCHIZUKI, H ;
NISHI, T ;
BRUNER, JM ;
LEE, PSY ;
LEVIN, VA ;
SAYA, H .
MOLECULAR CARCINOGENESIS, 1992, 6 (02) :83-87
[10]  
NISHI T, 1991, ONCOGENE, V6, P1555