NEUROFIBROMATOSIS-1 MESSENGER-RNA EXPRESSION IN BLOOD-VESSELS

被引：15

作者：

AHLGRENBECKENDORF, JA

MAGGIO, WW

CHEN, F

KENT, TA

机构：

[1] UNIV TEXAS,MED BRANCH,DEPT NEUROL,GALVESTON,TX 77555

[2] UNIV TEXAS,MED BRANCH,DEPT SURG,DIV NEUROSURG,GALVESTON,TX 77555

[3] UNIV TEXAS,MED BRANCH,DEPT PSYCHIAT,GALVESTON,TX 77555

[4] UNIV TEXAS,MED BRANCH,DEPT PHARMACOL,GALVESTON,TX 77555

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 197卷 / 02期

关键词：

D O I：

10.1006/bbrc.1993.2580

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vascular hypertrophic lesions occur in neurofibromatosis type 1 (NF1). The role of the gene which causes NF1 in the growth and development of blood vessels is not known. mRNA expression of the NF1 gene was studied in blood vessels in the transition between intact and culture and in quiescent and proliferative conditions. The expression and alternative splicing pattern of the catalytic domain of NF1 consistently changed in proliferating cells, supporting a role for this gene in the regulation of growth of vascular smooth muscle and the vascular pathology in NF1. © 1993 Academic Press, Inc.

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页码：1019 / 1024

页数：6

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