MOTOR RESPONSIVENESS OF PROXIMAL AND DISTAL HUMAN COLONIC MUSCLE LAYERS TO ACETYLCHOLINE, NORADRENALINE, AND VASOACTIVE-INTESTINAL-PEPTIDE

被引：13

作者：

BURLEIGH, DE

机构：

[1] Department of Pharmacology, The London Hospital Medical College, London, El 2AD, Turner St.

来源：

DIGESTIVE DISEASES AND SCIENCES | 1990年 / 35卷 / 05期

关键词：

acetylcholine; colon; human; noradrenaline; regions; vasoactive intestinal peptide;

D O I：

10.1007/BF01540410

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

There is an increasing body of evidence suggesting regional heterogeneity in human colonic function. Using circular and longitudinal muscle strips from proximal and distal human colon, the present study sought to determine whether such regional differences were apparent in smooth muscle responsiveness to neurohumoral agents. Both proximal and distal muscle gave quantitatively similar responses to acetylcholine, as they did for noradrenaline. However, the circular muscle of the distal colon was more sensitive to vasoactive intestinal peptide than was the circular muscle of the proximal colon. Longitudinal muscle from both regions was comparatively insensitive to VIP. © 1990 Plenum Publishing Corporation.

引用

页码：617 / 621

页数：5

共 20 条

[1] IS VASOACTIVE INTESTINAL PEPTIDE AN INHIBITORY TRANSMITTER IN THE CIRCULAR BUT NOT THE LONGITUDINAL MUSCLE OF GUINEA-PIG COLON [J].