NOVEL MEROTERPENOIDS FROM CYSTOSEIRA-MEDITERRANEA - USE OF THE CROWN-GALL BIOASSAY AS A PRIMARY SCREEN FOR LIPOPHILIC ANTINEOPLASTIC AGENTS

被引:23
作者
FADLI, M [1 ]
ARACIL, JM [1 ]
JEANTY, G [1 ]
BANAIGS, B [1 ]
FRANCISCO, C [1 ]
机构
[1] UNIV PERPIGNAN,LAB CHIM MARINE GERAP,F-66025 PERPIGNAN,FRANCE
来源
JOURNAL OF NATURAL PRODUCTS | 1991年 / 54卷 / 01期
关键词
MARINE-ALGAE; POTATO;
D O I
10.1021/np50073a029
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Using a slight modification of the crown-gall potato disc bioassay, we were able to apply this test for two previously described antineoplastic lipophilic metabolites, didemnin B and mediterraneol A [1], and to use it as a guide for chromatographic separations of meroterpenoids from Cystoseira mediterranea. An active compound, mediterraneone [3], was isolated, and its structure was found to be a novel norsesquiterpenoid by chemical and spectral methods.
引用
收藏
页码:261 / 264
页数:4
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