SHORT TIME-SCALE LEFT-VENTRICULAR SYSTOLIC DYNAMICS - EVIDENCE FOR A COMMON MECHANISM IN BOTH LEFT-VENTRICULAR CHAMBER AND HEART-MUSCLE MECHANICS

被引:22
作者
CAMPBELL, KB [1 ]
SHROFF, SG [1 ]
KIRKPATRICK, RD [1 ]
机构
[1] UNIV CHICAGO,CARDIOL SECT,CHICAGO,IL 60637
关键词
ISOLATED HEART; LEFT VENTRICLE; CARDIAC MECHANICS; MATHEMATICAL MODELS; FERRETS;
D O I
10.1161/01.RES.68.6.1532
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Based on the premise that short-time-scale, small-amplitude pressure/volume/outflow behavior of the left ventricular chamber was dominated by dynamic processes originating in cardiac myofilaments, a prototype model was built to predict pressure responses to volume pertubations. In the model, chamber pressure was taken to be the product of the number of generators in a pressure-bearing state and their average volumetric distrotion, as in the muscle theory of A.F. Huxley, in which force was equal to the number of attached crossbridges and their average lineal distortion. Further, as in the muscle theory, pressure generators were assumed to cycle between two states, the pressure-bearing state and the non-pressure-bearing state. Experiments were performed in the isolated ferret heart, where variable volume decrements (0.01-0.12 ml) were removed at two commanded flow rates (flow clamps, -7 and -14 ml/sec). Pressure responses to volume removals were analyzed. Although the prototype model accounted for most features of the pressure responses, subtle but systematic discrepancies were observed. The presence or absence of flow and the magnitude of flow affected estimates of model parameters. However, estimates of parameters did not differ when the model was fitted to flow clamps with similar magnitudes of flows but different volume changes. Thus, prototype model inadequacies were attributed to misrepresentation of flow-related effects but not of volume-related effects. Based on these discrepancies, an improved model was built that added to the simple two-state cycling scheme, a pathway to a third state. This path was followed only in response to volume change. The improved model eliminated the deficiencies of the prototype model and was adequate in accounting for all observations. Since the template for the improved model was taken from the cycling crossbridge theory of muscle contraction, it was concluded that, in spite of the complexities of geometry, architecture, and regional heterogeneity of function and structure, crossbridge mechanisms dominated the short-time-scale dynamics of left ventricular chamber behavior.
引用
收藏
页码:1532 / 1548
页数:17
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