POTENT INHIBITORS OF PLATELET-AGGREGATION BASED UPON THE ARG-GLY-ASP-PHE SEQUENCE OF FIBRINOGEN - A PROPOSAL ON THE NATURE OF THE BINDING INTERACTION BETWEEN THE ASP-CARBOXYLATE OF RGDX MIMETICS AND THE PLATELET GP IIB-IIIA RECEPTOR

被引:48
作者
ZABLOCKI, JA [1 ]
MIYANO, M [1 ]
RAO, SN [1 ]
PANZERKNODLE, S [1 ]
NICHOLSON, N [1 ]
FEIGEN, L [1 ]
机构
[1] SEARLE RES & DEV,DEPT PHARMACOL,SKOKIE,IL 60077
关键词
D O I
10.1021/jm00104a019
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:4914 / 4917
页数:4
相关论文
共 18 条
[1]  
ADAMS SP, 1989, Patent No. 30319506
[2]  
ANDRIEUX A, 1989, J BIOL CHEM, V264, P9258
[3]  
ANDRIEUX A, 1989, C INSERM, V174, P567
[4]   CALCULATION OF THE RELATIVE CHANGE IN BINDING FREE-ENERGY OF A PROTEIN-INHIBITOR COMPLEX [J].
BASH, PA ;
SINGH, UC ;
BROWN, FK ;
LANGRIDGE, R ;
KOLLMAN, PA .
SCIENCE, 1987, 235 (4788) :574-576
[5]   A DISCRETE SEQUENCE IN A PLATELET INTEGRIN IS INVOLVED IN LIGAND RECOGNITION [J].
DSOUZA, SE ;
GINSBERG, MH ;
MATSUEDA, GR ;
PLOW, EF .
NATURE, 1991, 350 (6313) :66-68
[6]  
Farmer P. S., 1980, DRUG DESIGN, VX, P119
[7]  
FEIGEN L P, 1989, FASEB Journal, V3, pA309
[8]  
INMAN JK, 1981, PEPTIDES ANAL SYNTHE, V3, P277
[9]   POLYPEPTIDES .11. TETRAZOLE ANALOGUES OF C-TERMINAL TETRAPEPTIDE AMIDE SEQUENCE OF GASTRINS [J].
MORLEY, JS .
JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1969, (05) :809-&
[10]  
PHILLIPS DR, 1988, BLOOD, V71, P831