FAMILIAL CANCER AGGREGATION IN CASES OF ADENOCARCINOMA CORPORIS UTERI

被引:32
作者
Boltenberg, Anette [1 ]
Furgyik, Stefan [1 ]
Kullander, Stig [1 ]
机构
[1] Malmo Gen Hosp, Dept Obstet & Gynecol, S-21401 Malmo, Sweden
关键词
D O I
10.3109/00016349009028689
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
In a detailed prospective interview study, all newly diagnosed cases of adenocarcinoma corporis uteri at Malmo during a 2-year period (n = 51) were analysed with regard to the occurrence of tumors in first-degree relatives. The families of the proband's male consorts were used as controls. Sisters and mothers of probands had tumors (particularly of the corpus uteri or breast) more often than had controls. Colon and prostate cancer also figured in family histories of proband relatives, more often and with earlier age at onset than in controls. Nine patients (18%) either had additional concomitant malignancies, or had had such malignancies previously. Familial cancer predisposition was associated with poorly differentiated anaplastic cancer of the corpus uteri with poor prognosis. Three cases of familial cancer (CFS) observed at Malmo are also described, in which the probands presented with adenocarcinoma corporis uteri. The findings suggest that a hereditary, cancerpredisposing factor (gene) is involved in a significant proportion of cancer corporis uteri, and that it is expressed in a heterogeneous tumor pattern, predominantly at sites sensitive to hormonal influences.
引用
收藏
页码:249 / 258
页数:10
相关论文
共 23 条
  • [1] ANNEGERS JF, 1981, CANCER, V48, P856, DOI 10.1002/1097-0142(19810801)48:3<856::AID-CNCR2820480332>3.0.CO
  • [2] 2-4
  • [3] ABO BLOOD GROUPS AND CANCER OF FEMALE GENITAL TRACT
    BERGSJO, P
    KOLSTAD, P
    [J]. ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 1962, 41 (04) : 397 - &
  • [4] BLOW S, 1981, UGESKRIFT LAEGER, V143, P2716
  • [5] BROBECK O, 1949, THESIS U COPENHAGEN
  • [6] FAMILIAL OCCURRENCE OF CERVICAL-CANCER, STAGES-0-IV
    FURGYIK, S
    GRUBB, R
    KULLANDER, S
    SANDAHL, B
    WINGERUP, L
    EYDAL, A
    [J]. ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 1986, 65 (03) : 223 - 227
  • [7] Hasselgren P O, 1984, Lakartidningen, V81, P2451
  • [8] KAUPPILA A, 1982, OBSTET GYNECOL, V60, P473
  • [10] FAMILIAL EXCESS OF CANCER OF THE OVARY AND OTHER ANATOMIC SITES
    LYNCH, HT
    ALBANO, W
    BLACK, L
    LYNCH, JF
    RECABAREN, J
    PIERSON, R
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1981, 245 (03): : 261 - 264