CONTINUOUS-FLOW CHEMILUMINOMETRIC DETERMINATION OF DIHYDRALAZINE, RIFAMPICIN AND RIFAMYCIN SV BY OXIDATION WITH N-BROMOSUCCINIMIDE

被引：39

作者：

HALVATZIS, SA ^{[1
]}

TIMOTHEOUPOTAMIA, MM ^{[1
]}

HADJIIOANNOU, TP ^{[1
]}

机构：

[1] UNIV ATHENS,ANALYT CHEM LAB,GR-15771 ATHENS,GREECE

来源：

ANALYTICA CHIMICA ACTA | 1993年 / 272卷 / 02期

关键词：

CHEMILUMINESCENCE; FLOW SYSTEM; DIHYDRALAZINE; PHARMACEUTICALS; RIFAMPICIN; RIFAMYCIN;

D O I：

10.1016/0003-2670(93)80577-8

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A continuous-flow chemiluminometric method for the determination of dihydralazine sulphate (2.00-30.0 mug ml-1), rifampicin (0.0200-1.00 mug ml-1) and rifamycin SV (0.00500-1.00 mug ml-1) is described. The solutions are allowed to stand for about 4 h in alkaline solution before measurement in order to degrade to chemiluminogenic products. The method is based on the chemiluminescence produced during oxidation of these products by N-bromosuccinimide in alkaline medium. The emission intensity is greatly enhanced by the presence of ammonia. The procedure is automated and solutions can be analysed at a rate of 105 h-1 with a relative error of 1-3%. The method was evaluated by carrying out an interference study with common excipients and other co-existing compounds, by a recovery study and by the analysis of commercial formulations. The results obtained compared well with those obtained by an official method and demonstrated good accuracy and precision.

引用

页码：251 / 263

页数：13

共 26 条

[1] DETERMINATION OF MORPHINE BY FLOW-INJECTION ANALYSIS WITH CHEMILUMINESCENCE DETECTION [J].