Effects of Dopamine Reuptake Inhibitors on Food- and Cocaine-Maintained Responding: II. Comparisons With Other Drugs and Repeated Administrations

被引:66
作者
Glowa, John R. [1 ]
Wojnicki, Francis H. E. [1 ]
Matecka, Dorota [1 ]
Rice, Kenner C. [1 ]
Rothman, Richard B. [2 ]
机构
[1] NIDDK, Lab Med Chem, NIH, Bethesda, MD USA
[2] NIDA, Clin Psychopharmacol Sect, Addict Res Ctr, Baltimore, MD USA
关键词
D O I
10.1037/1064-1297.3.3.232
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
A previous study (J.R. Glowa, F.H.E. Wojnicki, D. Matecka, et al, 1995) showed that acute doses of GBR 12909 selectively decreased cocaine-maintained responding without affecting food-maintained responding. This report extended these observations to some related drugs and to the effects of repeated administration. When responding was maintained under a multiple fixed ratio (FR) 30 food, FR 30 cocaine schedule, acute doses of GBR 12935, CFT, and d-amphetamine decreased cocaine-maintained responding more than food-maintained responding. However, in contrast to GBR 12909, none of these drugs completely decreased cocaine-maintained responding without affecting food-maintained responding. Repeated administration of GBR 12909 sustained, and of GBR 12935 improved, these selective decreases in cocaine-maintained responding. The selective effect of these dopamine reuptake inhibitors on cocaine-maintained responding is consistent with their known pharmacological selectivity for the dopamine reuptake site and can be well-maintained with repeated administration.
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页码:232 / 239
页数:8
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