HUMAN PLACENTA CONTAINS AN EPITHELIAL SCATTER PROTEIN

被引：40

作者：

ROSEN, EM

MEROMSKY, L

ROMERO, R

SETTER, E

GOLDBERG, I

机构：

[1] LONG ISL JEWISH MED CTR,DEPT RADIAT ONCOL,NEW HYDE PK,NY 11042

[2] YALE UNIV,SCH MED,DEPT OBSTET & GYNECOL,NEW HAVEN,CT 06510

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 168卷 / 03期

关键词：

D O I：

10.1016/0006-291X(90)91140-N

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Scatter factor (SF) is a protein produced by cultured fibroblasts which causes epithelia to "scatter" into isolated cells. We found significant scatter activity invivo in second trimester (but not term) human amniotic fluid and in human placenta. Placental SF was purified 500,000-fold and identified as a protein with Mr 78 kd. Factor scattered Madin-Darby canine kidney and human squamous carcinoma cells at 15 pM. Amino acid sequences from tryptic peptides did not match any known protein. Human placental fibroblasts produced high titers of scatter activity. SF may be involved in development and may enhance carcinoma invasion. © 1990.

引用

页码：1082 / 1088

页数：7

共 13 条

[1] CHEMOTACTIC RESPONSE OF RAT MAMMARY ADENOCARCINOMA CELL CLONES TO TUMOR-DERIVED CYTOKINES [J].