ACTIVATION-ENERGIES AND FORMATION RATE CONSTANTS FOR ORGANIC ARSENICAL ANTIDOTE ADDUCTS AS DETERMINED BY DYNAMIC NMR-SPECTROSCOPY

被引：8

作者：

DILL, K ^{[1
]}

HUANG, LH ^{[1
]}

BEARDEN, DW ^{[1
]}

MCGOWN, EL ^{[1
]}

OCONNOR, RJ ^{[1
]}

机构：

[1] LETTERMAN ARMY INST RES, CHEM BRANCH, SAN FRANCISCO, CA 94129 USA

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 1991年 / 4卷 / 03期

关键词：

D O I：

10.1021/tx00021a006

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Phenyldichloroarsine reacts with 1,3-dimercapto-2-propanol and 1,2-dimercaptopropane to form 1:1 adducts in the form of a six-membered and five-membered heteroatom rings. Two geometric isomers for each compound are present in dynamic equilibrium. Rate constants and the activation barriers for the interconversion of the geometric isomers were determined by dynamic NMR spectroscopy. The activation barriers indicate that the five-membered heteroatom ring is more stable than the six-membered heteroatom ring.

引用

页码：295 / 299

页数：5

共 20 条

[1]

ADAMS ER, 1988, THESIS CLEMSON U

[2] NMR-STUDIES ON CYCLIC ARSENITES - H-1-NMR SPECTRAL ANALYSIS AND CONFORMATIONAL STUDIES OF 22 1,3,2-DIOXARSENANES [J].

AKSNES, DW ;

BERGESEN, K ;

STROMME, O .

ACTA CHEMICA SCANDINAVICA SERIES A-PHYSICAL AND INORGANIC CHEMISTRY, 1979, 33 (06) :413-420

[3]

ATTAURRAHMAN, 1986, NUCLEAR MAGNETIC RES

[4] 2,3-DITHIOERYTHRITOL, A POSSIBLE NEW ARSENIC ANTIDOTE [J].

BOYD, VL ;

HARBELL, JW ;

OCONNOR, RJ ;

MCGOWN, EL .

CHEMICAL RESEARCH IN TOXICOLOGY, 1989, 2 (05) :301-306

[5] FOURIER-TRANSFORM NMR PULSE METHODS FOR MEASUREMENT OF SLOW-EXCHANGE RATES [J].

CAMPBELL, ID ;

DOBSON, CM ;

RATCLIFFE, RG ;

WILLIAMS, RJP .

JOURNAL OF MAGNETIC RESONANCE, 1978, 29 (03) :397-417

[6]

DALLING DK, 1971, J AM CHEM SOC, V93, P3678

[7]

Demas J.N., 1983, EXCITED STATE LIFETI

[8] ONE-DIMENSIONAL AND TWO-DIMENSIONAL NUCLEAR-MAGNETIC-RESONANCE STUDIES OF THE REACTION OF PHENYLDICHLOROARSINE WITH GLUTATHIONE [J].

DILL, K ;

ADAMS, ER ;

OCONNOR, RJ ;

CHONG, S ;

MCGOWN, EL .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1987, 257 (02) :293-301

[9] 2D NMR-STUDIES OF THE PHENYLDICHLOROARSINE-BRITISH ANTI-LEWISITE ADDUCT [J].

DILL, K ;

ADAMS, ER ;

OCONNOR, RJ ;

MCGOWN, EL .

MAGNETIC RESONANCE IN CHEMISTRY, 1987, 25 (12) :1074-1077

[10] STRUCTURE AND DYNAMICS OF A LIPOIC ACID-ARSENICAL ADDUCT [J].

DILL, K ;

ADAMS, ER ;

OCONNOR, RJ ;

MCGOWN, EL .

CHEMICAL RESEARCH IN TOXICOLOGY, 1989, 2 (03) :181-185

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