ANTICONVULSANT ACTION OF AN ARYLAMINE-CONTAINING FRACTION FROM AGELENOPSIS SPIDER VENOM

被引：18

作者：

JACKSON, H ^{[1
]}

PARKS, TN ^{[1
]}

机构：

[1] UNIV UTAH, SCH MED, DEPT ANAT, SALT LAKE CITY, UT 84132 USA

来源：

BRAIN RESEARCH | 1990年 / 526卷 / 02期

关键词：

D O I：

10.1016/0006-8993(90)91243-A

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A low molecular weight fraction (AG2) containing arylamine compounds has been isolated from venom of the spider Agelenopsis aperta. When administered intravenously or intracerebroventricularly, AG2 produces dose-dependent suppression of behavioral convulsions induced in rats by kainic acid, picrotoxin, or bicuculline. The low molecular weight compounds in spider venoms may provide novel tools for anticonvulsant research and therapy. © 1990.

引用

页码：338 / 341

页数：4

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