DEBRISOQUINE OXIDATION PHENOTYPE AND SUSCEPTIBILITY TO LUNG-CANCER

被引：59

作者：

SPEIRS, CJ ^{[1
]}

MURRAY, S ^{[1
]}

DAVIES, DS ^{[1
]}

MABADEJE, AFB ^{[1
]}

BOOBIS, AR ^{[1
]}

机构：

[1] ROYAL POSTGRAD MED SCH, DEPT CLIN PHARMACOL, DU CANE RD, LONDON W12 0NN, ENGLAND

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1990年 / 29卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1111/j.1365-2125.1990.tb03608.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. It has been suggested that poor metabolisers of debrisoquine are at reduced risk of developing lung cancer from smoking cigarettes. This has been investigated in 82 patients with established cancer of the lung. 2. The frequency of poor metaboliser subjects was not different from that in the normal population. 3. There was no tendency for subjects with lung cancer to metabolise debrisoquine more rapidly than non‐cancer subjects. 4. It is concluded that debrisoquine metabolic phenotype is not a good predictor of risk of developing lung cancer in the population at large. 1990 The British Pharmacological Society

引用

页码：101 / 109

页数：9

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