PULMONARY-ARTERY OCCLUSION IS SUFFICIENT TO INCREASE PULMONARY VASCULAR-PERMEABILITY IN RABBITS

被引:12
作者
BISHOP, MJ
LAMM, W
GUIDOTTI, SM
ALBERT, RK
机构
[1] UNIV WASHINGTON, SCH MED, DEPT ANESTHESIOL, SEATTLE, WA 98104 USA
[2] UNIV WASHINGTON, SCH MED, DEPT MED PULM & CRIT CARE, SEATTLE, WA 98104 USA
[3] UNIV WASHINGTON, SCH MED, VET AFFAIRS MED SERV, MED SERV, SEATTLE, WA 98104 USA
关键词
PULMONARY EDEMA; REPERFUSION; ISCHEMIA;
D O I
10.1152/jappl.1992.73.1.272
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Unilateral pulmonary artery obstruction (PAO) for 24-48 h, followed by reperfusion, results in pulmonary edema and lung inflammation. We hypothesized that lung injury actually occurred during the period of PAO but, because of low microvascular pressures during the period of occlusion, was not detected until perfusion was reestablished. To test this hypothesis, we studied 14 rabbits divided into three groups: group I rabbits underwent sham occlusion of the left pulmonary artery for 24 h; group II rabbits underwent PAO but were not reperfused; and group III rabbits were subjected to PAO and then reperfused for 4 h. The fluid filtration coefficient measured during a zone 3 no-flow hydrostatic stress (pulmonary arterial pressure = pulmonary venous pressure, both greater than alveolar pressure) in group I lungs was less than that of lungs in either group II or III [0.52 +/- 0.02 (SE) ml . min-1 . cmH2O . 100 g wet wt-1 vs. 0.94 +/- 0.11 and 0.86 +/- 0.13 for groups II and III, respectively, P < 0.05]. The wet-to-dry weight ratio of the left lung measured after the zone 3 stress was applied for 20 min was 6.90 +/- 0.09 in group I rabbits and 9.21 +/- 0.75 and 11.75 +/- 0.44 in groups II and III, respectively (P < 0.05). Radiolabeled microspheres demonstrated that flow to the left lung was diminished after the period of PAO (38 +/- 4, 9 +/- 5, and 2 +/- 1% of cardiac output in groups I, II, and III, respectively; P < 0.05 for group I vs. groups II and III). Low flow may protect against edema formation unless left atrial pressure is elevated and suggests that studies of vascular permeability after PAO may be markedly affected by changes in vascular surface area. We conclude that an ischemic injury occurs during PAO, before the period of reperfusion.
引用
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页码:272 / 275
页数:4
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