PHOSPHOLIPASE-A2 ACTIVITY IN EPSTEIN-BARR-VIRUS TRANSFORMED LYMPHOBLAST CELLS FROM SCHIZOPHRENIC-PATIENTS

被引：20

作者：

BENNETT, ER

YEDGAR, S

LERER, B

EBSTEIN, RP

机构：

[1] SARA HERZOG HOSP,DEPT GERIATR,POB 140,JERUSALEM,ISRAEL

[2] SARA HERZOG HOSP,DEPT PSYCHIAT RES,JERUSALEM,ISRAEL

[3] HEBREW UNIV JERUSALEM,HADASSAH MED SCH,DEPT BIOCHEM,IL-91010 JERUSALEM,ISRAEL

来源：

BIOLOGICAL PSYCHIATRY | 1991年 / 29卷 / 11期

关键词：

D O I：

10.1016/0006-3223(91)90247-J

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the activity of phospholipase A2 in Epstein-Barr virus-transformed lymphoblast cell lines established from ten schizophrenic patients and ten controls. A novel method for determination of enzyme activity in whole cells was employed, by measuring the hydrolysis of a fluorescent analogue of phosphatidylcholine. No significant difference in phospholipase A2 activity was found between the groups. These results suggest that the previously reported changes in phospholipase A2 activity in plasma and in fresh peripheral cells are indicative of environmental influences and not of "trait" characteristics intrinsic to schizophrenia.

引用

页码：1058 / 1062

页数：5

共 20 条

[1] RECEPTOR-MEDIATED ACTIVATION OF PHOSPHOLIPASE-A2 VIA GTP-BINDING PROTEINS - ARACHIDONIC-ACID AND ITS METABOLITES AS 2ND MESSENGERS [J].