SELECTIVE DEPENDENCE OF MAMMALIAN DORSAL-ROOT GANGLION NEURONS ON NERVE GROWTH-FACTOR DURING EMBRYONIC-DEVELOPMENT

被引:220
作者
RUIT, KG
ELLIOTT, JL
OSBORNE, PA
YAN, Q
SNIDER, WD
机构
[1] WASHINGTON UNIV,SCH MED,DEPT MOLEC BIOL & PHARMACOL,ST LOUIS,MO 63110
[2] AMGEN INC,THOUSAND OAKS,CA 91320
关键词
D O I
10.1016/0896-6273(92)90284-K
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We have investigated the NGF dependence of dorsal root ganglion (DRG) neurons in mammals using a paradigm of multiple in utero injections of a high titer anti-NGF antiserum. We have determined the specificity of our antiserum in relation to other members of the NGF neurotrophin family and found no cross-reactivity with brain-derived neurotrophic factor (BDNF) or neurotrophin-3 (NT-3). To identify various classes of DRG neurons, we have stained their characteristic central projections with Dil. We show here that the NGF dependence of DRG neurons is strikingly selective. Although a majority of DRG neurons are lost after NGF deprivation during embryonic life, these are almost exclusively small diameter neurons that project to laminae I and II of the dorsal horn and presumably subserve nociception and thermo-reception. Larger neurons that project to more ventral spinal laminae and subserve other sensory modalities do not require NGF for survival. These NGF-independent DRG neurons likely require one of the more recently identified neurotrophins, BDNF or NT-3.
引用
收藏
页码:573 / 587
页数:15
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