ENDOTHELIAL-CELL ADHESION TO ION-IMPLANTED POLYMERS

被引：78

作者：

SUZUKI, Y ^{[1
]}

KUSAKABE, M ^{[1
]}

LEE, JS ^{[1
]}

KAIBARA, M ^{[1
]}

IWAKI, M ^{[1
]}

SASABE, H ^{[1
]}

机构：

[1] RIKEN INST PHYS & CHEM RES,WAKO,SAITAMA 35101,JAPAN

来源：

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS | 1992年 / 65卷 / 1-4期

关键词：

D O I：

10.1016/0168-583X(92)95027-O

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

The biocompatibility of ion implanted polymers has been studied by means of adhesion measurements of bovine aorta endothelial cells in vitro. The specimens used were polystyrene (PS) and segmented polyurethane (SPU). Na+, N2+, O2+ and Kr+ ion implantations were performed at an energy of 150 keV with fluences ranging from 1 x 10(15) to 3 x 10(17) ions/cm2 at room temperature. The chemical and physical structures of ion-implanted polymers have been investigated in order to analyze their tissue compatibility such as improvement of endothelial cell adhesion. The ion implanted SPU have been found to exhibit remarkably higher adhesion and spreading of endothelial cells than unimplanted specimens. By contrast, ion implanted PS demonstrated a little improvement of adhesion of cells in this assay. Results of FT-IR-ATR showed that ion implantation broke the original chemical bond to form new radicals such as OH, Bond C C = O, SiH and condensed rings. The results of Raman spectroscopy showed that ion implantation always produced a peak near 1500 cm-1, which indicated that these ion implanted PS and SPU had the same carbon structure. This structure is considered to bring the dramatic increase in the extent of cell adhesion and spreading to these ion implanted PS and SPU.

引用

页码：142 / 147

页数：6

共 12 条

[1] MODELING STUDIES OF AMORPHOUS-CARBON [J].