MAPPING OF A GENE PREDISPOSING TO EARLY-ONSET ALZHEIMERS-DISEASE TO CHROMOSOME 14Q24.3

被引：293

作者：

VAN BROECKHOVEN, C

BACKHOVENS, H

CRUTS, M

DEWINTER, G

BRUYLAND, M

CRAS, P

MARTIN, JJ

机构：

[1] INNOGENET INC, B-9052 GENT, BELGIUM

[2] CITY HOSP RONSE, DEPT NEUROL, B-9600 RONSE, BELGIUM

[3] UNIV BRUSSELS, DEPT NEUROL, B-1090 BRUSSELS, BELGIUM

[4] UNIV ANTWERP, DEPT MED, BORN BUNGE FDN, NEUROBIOL LABS, B-2610 ANTWERP, BELGIUM

[5] UNIV ANTWERP, DEPT MED, BORN BUNGE FDN, NEUROPATHOL LABS, B-2610 ANTWERP, BELGIUM

来源：

NATURE GENETICS | 1992年 / 2卷 / 04期

关键词：

D O I：

10.1038/ng1292-335

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genetic linkage studies with chromosome 21 DNA markers and mutation analysis of the beta-amyloid protein precursor gene located in 21q21.3 have indicated that early-onset Alzheimer's disease (EOAD) is a heterogeneous disorder for which at least one other chromosomal locus exists. We examined two extended histopathologically confirmed EOAD pedigrees, AD/A and AD/B, with highly informative short tandem repeat (STR) polymorphisms and found complete linkage of the disease to a (CA)n dinucleotide repeat polymorphism at locus D14S43 in 14q24.3 (Z(max) = 13.25 at 0 = 0.0). Using additional chromosome 14 STR polymorphisms we were able to delineate the region containing the EOAD gene to an area of, at most, 8.9 centiMorgans between D14S42 and D14S53, flanking D14S43 on both sides.

引用

页码：335 / 339

页数：5

共 37 条

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