ALTERATIONS OF BRAIN-METABOLITES IN METACHROMATIC LEUKODYSTROPHY AS DETECTED BY LOCALIZED PROTON MAGNETIC-RESONANCE SPECTROSCOPY IN-VIVO

被引：93

作者：

KRUSE, B ^{[1
]}

HANEFELD, F ^{[1
]}

CHRISTEN, HJ ^{[1
]}

BRUHN, H ^{[1
]}

MICHAELIS, T ^{[1
]}

HANICKE, W ^{[1
]}

FRAHM, J ^{[1
]}

机构：

[1] MAX PLANCK INST BIOPHYS CHEM,D-37085 GOTTINGEN,GERMANY

来源：

JOURNAL OF NEUROLOGY | 1993年 / 241卷 / 02期

关键词：

METACHROMATIC LEUKODYSTROPHY; MYOINOSITOL BRAIN METABOLISM; MAGNETIC RESONANCE IMAGING; PROTON MAGNETIC RESONANCE SPECTROSCOPY;

D O I：

10.1007/BF00869766

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The brain morphology and chemistry of seven children with late infantile (4/7) and juvenile (3/7) forms of metachromatic leukodystrophy (MLD) were investigated by magnetic resonance imaging (MRI) and localized proton magnetic resonance spectroscopy (MRS). Patients who were examined at least 6 months after the onset of symptoms (6/7) had severe leukodystrophic changes on MRI. Proton MRS revealed a marked reduction of the neuronal marker N-acetylaspartate in white and grey matter and elevated lactate in demyelinated areas. In contrast to other leukodystrophies MLD patients showed a generalized increase of brain myo-inositol (2- to 3-fold in white matter), indicating a specific role in the pathophysiology of demyelination in MLD.

引用

页码：68 / 74

页数：7

共 28 条

[1] BRAND A, 1992, 11TH SOC MAGN RES ME, P649
[2] MULTIPLE-SCLEROSIS IN CHILDREN - CEREBRAL METABOLIC ALTERATIONS MONITORED BY LOCALIZED PROTON MAGNETIC-RESONANCE SPECTROSCOPY INVIVO
BRUHN, H
FRAHM, J
MERBOLDT, KD
HANICKE, W
HANEFELD, F
CHRISTEN, HJ
KRUSE, B
BAUER, HJ
[J]. ANNALS OF NEUROLOGY, 1992, 32 (02) : 140 - 150
[3] CEREBRAL METABOLISM IN MAN AFTER ACUTE STROKE - NEW OBSERVATIONS USING LOCALIZED PROTON NMR-SPECTROSCOPY
BRUHN, H
FRAHM, J
GYNGELL, ML
MERBOLDT, KD
HANICKE, W
SAUTER, R
[J]. MAGNETIC RESONANCE IN MEDICINE, 1989, 9 (01) : 126 - 131
[4] PROTON NMR-SPECTROSCOPY OF CEREBRAL METABOLIC ALTERATIONS IN INFANTILE PEROXISOMAL DISORDERS
BRUHN, H
KRUSE, B
KORENKE, GC
HANEFELD, F
HANICKE, W
MERBOLDT, KD
FRAHM, J
[J]. JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1992, 16 (03) : 335 - 344
[5] BRUHN H, 1992, 11TH SOC MAGN RES ME, P235
[6] BRUHN H, 1991, 10TH SOC MAGN RES ME, P400
[7] CLEMENTS RS, 1973, LANCET, V1, P1137
[8] LONGITUDINAL NEUROPHYSIOLOGIC STUDIES IN A PATIENT WITH METACHROMATIC LEUKODYSTROPHY FOLLOWING BONE-MARROW TRANSPLANTATION
DHUNA, A
TORO, C
TORRES, F
KENNEDY, WR
KRIVIT, W
[J]. ARCHIVES OF NEUROLOGY, 1992, 49 (10) : 1088 - 1092
[9] IMPROVEMENTS IN LOCALIZED PROTON NMR-SPECTROSCOPY OF HUMAN BRAIN - WATER SUPPRESSION, SHORT ECHO TIMES, AND 1-ML RESOLUTION
FRAHM, J
MICHAELIS, T
MERBOLDT, KD
BRUHN, H
GYNGELL, ML
HANICKE, W
[J]. JOURNAL OF MAGNETIC RESONANCE, 1990, 90 (03): : 464 - 473
[10] FRAHM J, 1991, MAGNETIC RESONANCE I, P165

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