AWAKENING PROPERTIES OF MODAFINIL WITHOUT PARADOXICAL SLEEP REBOUND - COMPARATIVE-STUDY WITH AMPHETAMINE IN THE RAT

被引：60

作者：

TOURET, M

SALLANONMOULIN, M

JOUVET, M

机构：

[1] Department of Experimental Medicine, Claude Bernard University, 69008 Lyon

来源：

NEUROSCIENCE LETTERS | 1995年 / 189卷 / 01期

关键词：

MODAFINIL; AMPHETAMINE; SLEEP-WAKE CYCLE; RAT;

D O I：

10.1016/0304-3940(95)11448-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have studied the effect of modafinil and amphetamine, two waking drugs, on the sleep-wake cycle of the Sprague-Dawley rat. Both modafinil (64 or 128 mg/kg) and amphetamine (2.5 or 5 mg/kg) cause a dose dependent increase in wakefulness. However, amphetamine wakefulness is followed by a paradoxical sleep rebound on the injection day, whereas modafinil does not produce this effect. In modafinil-treated rats, the sleep pattern on the post-injection day is similar to that of controls, while that of amphetamine-treated rats is modified.

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页码：43 / 46

页数：4

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