CIS-PLATINUM(II) DIAMINE DICHLORIDE CAUSES MUTATION, TRANSFORMATION, AND SISTER-CHROMATID EXCHANGES IN CULTURED MAMMALIAN-CELLS

被引：84

作者：

TURNBULL, D ^{[1
]}

POPESCU, NC ^{[1
]}

DIPAOLO, JA ^{[1
]}

MYHR, BC ^{[1
]}

机构：

[1] NCI,BIOL BRANCH,PROGRAM CARCINOGENESIS RES,BETHESDA,MD 20014

来源：

MUTATION RESEARCH | 1979年 / 66卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0165-1218(79)90088-0

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The anti-tumor agent cis-platinum (II) diamine dichloride caused dose-dependent toxicity in V79 Chinese hamster cells and in secondary Syrian hamster embryo cells. Chromosome aberrations were induced and positive dose-response relationships were observed for induction of sister-chromatid exchanges and 6-thioguanine-resistant mutations in V79 cells and morphologic transformation of secondary Syrian hamster embryo cells. These findings suggest that this chemical is a potential human carcinogen. © 1979.

引用

页码：267 / 275

页数：9

共 17 条

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