GENETIC-EFFECTS ON CARDIOVASCULAR-RESPONSES TO COLD AND MENTAL ACTIVITY IN LATE ADULTHOOD

被引：22

作者：

CARMELLI, D

WARD, MM

REED, T

GRIM, CE

HARSHFIELD, GA

FABSITZ, RR

机构：

[1] SRI International, Menlo Park, CA

[2] Department of Medical Genetics, Indiana University, Indianapolis

[3] Hypertension Research Center, Charles R. Drew University of Medicine and Science, Los Angeles, CA

[4] Department of Pediatrics, University of Tennessee, Memphis

[5] Division of Epidemiology and Clinical Applications, National Heart, Blood Institute, Bethesda, MD

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1991年 / 4卷 / 03期

关键词：

Blood pressure; Heart rate; Heritability; Reactivity; Twins;

D O I：

10.1093/ajh/4.3.239

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The purpose of the present investigation was to examine the genetic contributions to cardiovascular reactivity in an adult cohort of male twins. A total of 47 monozygotic (MZ) twin pairs and 54 dizygotic (DZ) twin pairs, aged 59 to 69 years, were laboratory tested at four sites as part of the third examination of the National Heart, Lung, and Blood Institute Twin Study. Systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) were recorded during two tasks, a mental arithmetic task involving serial subtraction and the cold pressor test. Significant cardiovascular responsivity was observed during both tasks as measured by substantial elevations in SBP, DBP, and HR from resting periods to task periods. Heritability estimates were statistically significant for SBP and DBP but not HR levels during pretask baseline periods and during both tasks. Genetic variance was maintained for blood pressure reactivity to the mental arithmetic task after adjustments for baseline and performance. No genetic variance for SBP or DBP reactivity to the cold pressor test was evident.

引用

页码：239 / 244

页数：6

共 21 条

[1] Havlik R.J., Garrison R.J., Feinleib M., Et al., Blood pressure aggregation in families, Am J. Epidemiol, 110, pp. 304-312, (1979)
[2] Morton N.E., Gulbrandsen C.L., Rao D.C., Et al., Determinants of blood pressure in Japanese-American families, Hum Genet, 53, pp. 261-266, (1980)
[3] Weinberg R., Shear C.L., Avet L.M., Et al., Path analysis of environmental and genetic influences on blood pressure, Am J Epidemiol, 109, pp. 588-596, (1979)
[4] Keys A., Taylor H.L., Blackburn H., Et al., Mortality and coronary heart disease among men studied for 23 years, Arch Int Med, 128, pp. 201-214, (1971)
[5] McLlhany M.L., Shaffer J.W., Hines E.A., The heritability of blood pressure: An investigation of 200 pairs of twins using the cold pressor test, Johns Hopkins Med J, 136, pp. 57-64, (1975)
[6] Rose R.J., Miller J.Z., Grim C.E., Familial factors in blood pressure response to laboratory stress: A twin study (abst), Psychophysiology, 19, (1982)
[7] Carroll D., Hewitt J.K., Last K.A., Et al., A twin study of cardiac reactivity and its relationship to parental blood pressure, Physiol Behav, 34, pp. 103-106, (1985)
[8] Smith T.W., Turner C.W., Ford M.H., Et al., Blood pressure reactivity in adult male twins, Health Psychol, 6, pp. 209-220, (1987)
[9] Carmelli D., Chesney M.A., Ward M.M., Et al., Twin similarity in cardiovascular stress response, Health Psychol, 4, pp. 413-423, (1985)
[10] Province M.A., Rao D.C., A new model for the resolution of cultural and biological inheritance in the presence of temporal trends: Application to systolic blood pressure, Genet Epidemiol, 2, pp. 363-374, (1985)

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