CHARACTERIZATION OF THE BREAKPOINT OF A T(14-14)(Q11.2-Q32) FROM THE LEUKEMIC-CELLS OF A PATIENT WITH T-CELL ACUTE LYMPHOBLASTIC-LEUKEMIA

被引：27

作者：

BERTNESS, VL

FELIX, CA

MCBRIDE, OW

MORGAN, R

SMITH, SD

SANDBERG, AA

KIRSCH, IR

机构：

[1] USN HOSP,MED ONCOL BRANCH,NCI,BLDG 8,ROOM 5101,BETHESDA,MD 20814

[2] NCI,BIOCHEM LAB,BETHESDA,MD 20205

[3] SW BIOMED RES INST,SCOTTSDALE,AZ

[4] STANFORD UNIV,CHILDRENS HOSP,STANFORD,CA 94305

来源：

CANCER GENETICS AND CYTOGENETICS | 1990年 / 44卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0165-4608(90)90196-H

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The leukemic cells and derivative cell line from a 74-year-old male with T-cell acute lymphoblastic leukemia showed chromosomal abnormalities including a t(14;14)(q11.2;q32). This translocation is characteristic of a variety of T-cell malignancies, particularly T-cell prolymphocytic leukemia and the clonal proliferations of peripheral T cells in patients with ataxia-telangiectasia. Using DNA probes that spanned the T-cell receptor alpha chain (TCRA) joining (J) locus, the DNA rearrangement caused by the translocation was identified, cloned, and sequenced. The breakpoint shows site-specific juxtaposition of a TCRA joining segment and DNA from a region of 14q32 centromeric to the immunoglobulin heavy chain locus. Comparison of restriction map and nucleotide sequence from this translocation with other related chromosomal breakpoints suggests a dispersion of breakpoints throughout the 14q32 region. © 1990.

引用

页码：47 / 54

页数：8

共 27 条

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