ONE-FLASK SYNTHESES OF 6-THIOGUANOSINE AND 2'-DEOXY-6-THIOGUANOSINE

被引：30

作者：

KUNG, PP ^{[1
]}

JONES, RA ^{[1
]}

机构：

[1] RUTGERS STATE UNIV,DEPT CHEM,PISCATAWAY,NJ 08855

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 32期

关键词：

6-THIOGUANOSINE; 2'-DEOXY-6-THIOGUANOSINE; 2-AMINO-9-(2-DEOXY-BETA-D-ERYTHRO-PENTOFURANOSYL)PURINE;

D O I：

10.1016/0040-4039(91)80589-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have previously reported that reaction of guanosine or 2'-deoxyguanosine with trifluoroacetic anhydride in pyridine gives a putative 6-pyridyl intermediate from which several 6-substituted derivatives may be obtained.1 We now report high-yield conversion of guanosine and 2'-deoxyguanosine to the corresponding 6-thio compounds in a two-step, one-flask reaction via this 6-pyridyl intermediate. Standard Raney nickel treatment, as reported for the ribonucleoside,2 then gives the 2-aminopurine nucleosides.

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页码：3919 / 3922

页数：4

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