ANTI-ULCER AGENTS .2. PYRIDYL OXIME ETHERS

被引：9

作者：

MOFFETT, RB ^{[1
]}

ROBERT, A ^{[1
]}

SCHUMANN, EL ^{[1
]}

PAQUETTE, LA ^{[1
]}

机构：

[1] UPJOHN CO,RES LABS,KALAMAZOO,MI 49001

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1979年 / 16卷 / 07期

关键词：

D O I：

10.1002/jhet.5570160734

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A large number of pyridinecarboxaldehyde (and ketone) O‐substituted oximes were prepared by alkylating the oxime or by treating the parent aldehyde (or ketone) with an O‐substituted hydroxylamine. Many of these were converted to the N‐oxide. Screening revealed that many of these oxime ethers were active in preventing gastric ulcers in rats. Data on selected examples is given. Copyright © 1979 Journal of Heterocyclic Chemistry

引用

页码：1459 / 1467

页数：9

共 11 条

[1]

HAGEDORN VI, 1976, ARZNEIM FORSCH, V26, P1273

[2] ADDITIONEN VON ORGANOMETALLVERBINDUNGEN AN C EQUALS N-BINDUNG [J].

MARXER, A ;

HORVATH, M .

HELVETICA CHIMICA ACTA, 1964, 47 (04) :1101-&

[3]

MATHES W, Patent No. 3198803

[4]

MATHES W, 1963, Patent No. 2092

[5] ANTIULCER AGENTS - PARA AMINOBENZAMIDO AROMATIC COMPOUNDS [J].

MOFFETT, RB ;

ROBERT, A ;

SKALETZK.LL .

JOURNAL OF MEDICINAL CHEMISTRY, 1971, 14 (10) :963-&

[6] EXERTION ULCERS IN RAT [J].

ROBERT, A ;

NEZAMIS, JE ;

PHILLIPS, JP .

AMERICAN JOURNAL OF DIGESTIVE DISEASES, 1970, 15 (05) :497-+

[7] HYDROXYLAMINE CHEMISTRY .4. O-ARALKYLHYDROXYLAMINES [J].

SCHUMANN, EL ;

VELDKAMP, W ;

GREIG, ME ;

HEINZELMAN, RV .

JOURNAL OF MEDICINAL CHEMISTRY, 1964, 7 (03) :329-&

[8]

SCHUMANN EL, Patent No. 3205234

[9]

SCHUMANN EL, Patent No. 3167563

[10]

Steinhards A., US Patent, Patent No. 2924604

← 1 2 →