3-OXO-3H-INDOLE FROM DIOXYGEN COPPER-CATALYZED OXIDATION OF INDOLE - ONE-FLASK SYNTHESIS OF 2-DIALKYLAMINO 3-OXO-3H-INDOLES

被引：26

作者：

CAPDEVIELLE, P

MAUMY, M

机构：

[1] Laboratoire de Recherches Organiques de l'ESPCI, associé au CNRS, F - 75231 Paris Cedex 05

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 18期

关键词：

COPPER-CATALYZED OXIDATION; DIOXYGEN; INDOLE; 2-DIALKYLAMINO; 3-OXO; 3H-INDOLES;

D O I：

10.1016/S0040-4039(00)60490-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cu(I)Cl-catalyzed oxidation of indole 1 by dioxygen in anhydrous acetonitrile leads to highly reactive 3-oxo 3H- indole 2, which provides directly 2- dialkylamino 3- oxo 3H- indoles 3 in presence of dialkylamines. Amidines 3, previously difficult to prepare, are potentially useful synthons in the field of heterocyclic chemistry.

引用

页码：2953 / 2956

页数：4

共 15 条

[1] OXYGENATION OF INDOLES BY A COPPER(I) CHLORIDE PYRIDINE COMPLEX - A NEW TRYPTOPHAN 2,3-DIOXYGENASE MODEL SYSTEM [J].