BIEXPONENTIAL PULMONARY CLEARANCE OF TC-99M-DTPA INDUCED BY DETERGENT AEROSOL

被引:20
作者
EVANDER, E [1 ]
WOLLMER, P [1 ]
VALIND, S [1 ]
SORNMO, L [1 ]
JOHN, J [1 ]
JONSON, B [1 ]
机构
[1] LUND UNIV,DEPT CLIN PHYSIOL,S-21401 MALMO,SWEDEN
关键词
ALVEOLOCAPILLARY PERMEABILITY; LUNG FUNCTION; LUNG SURFACTANT; RABBITS; RADIONUCLIDE IMAGING; TC-99M-LABELED DIETHYLENETRIAMINE PENTAACETATIC ACID;
D O I
10.1152/jappl.1994.77.1.190
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
We measured the pulmonary clearance of technetium-99m-labeled diethylenetriamine pentaacetatic acid (Tc-99m-DTPA) for 3 h after perturbation of the surfactant system by administration of the detergent dioctyl sodium sulfosuccinate in aerosol. Forty-two rabbits were anesthetized with pentobarbital sodium. Tracheostomies were performed, and the rabbits were mechanically ventilated. Increasing concentrations of detergent (0.125-2%) or vehicle were given for 5 min, and clearance measurements were performed immediately or 60 min after detergent administration. No animals developed respiratory distress. After vehicle, the clearance was monoexponential with a half-life of 158 min. Detergent induced a biexponential clearance with a rapidly clearing additional pool of radioactivity with a half-life of 5-15 min. The relative amount of radioactivity clearing rapidly increased with detergent concentration. The detergent effect was partly reversible. We conclude that detergent induces a biexponential clearance of Tc-99m-DTPA by accelerating the transfer of tracer across the alveolocapillary barrier in a proportion of lung units in a dose-related manner.
引用
收藏
页码:190 / 196
页数:7
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