SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF COUMARIN AND BENZODIOXAZEPINE-SUBSTITUTED, DIAZAZEPINE-SUBSTITUTED AND BENZOXAZEPINE-SUBSTITUTED PENICILLINS

被引：52

作者：

BONSIGNORE, L

DELOGU, A

LOY, G

LAVAGNA, SM

SECCI, D

机构：

[1] UNIV CAGLIARI,DIPARTIMENTO SCI CHIRURG & TRAPIANTI ORGANO,SEZIONE MICROBIOL & VIROL,I-09124 CAGLIARI,ITALY

[2] UNIV ROMA LA SAPIENZA,DIPARTIMENTO CHIM & TECNOL SOSTANZE BIOL ATTIVE,I-00185 ROME,ITALY

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1994年 / 29卷 / 06期

关键词：

COUMARIN PENICILLIN; SCHIFF BASE; CARBON SUBOXIDE; ANTIMICROBIAL ACTIVITY;

D O I：

10.1016/0223-5234(94)90075-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Some semisynthetic penicillins 6-substituted with benzo-condensed heterocyclic derivatives were prepared using the reaction of carbon suboxide with Schiff bases and disubstituted benzoic acids. The microbiological assay performed with the penicillins and their intermediates showed a good activity for one Schiff base and a weak activity for the other compounds.

引用

页码：479 / 485

页数：7

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