DISCOVERY OF ANTICANCER AGENTS FROM NATURAL-PRODUCTS

被引：16

作者：

VALERIOTE, F

CORBETT, T

LORUSSO, P

MOORE, RE

SCHEUER, P

PATTERSON, G

PAUL, V

GRINDEY, G

BONJOUKLIAN, R

PEARCE, H

SUFFNESS, M

机构：

[1] WAYNE STATE UNIV,SCH MED,DIV HEMATOL & ONCOL,DETROIT,MI 48201

[2] UNIV HAWAII,DEPT CHEM,HONOLULU,HI 96822

[3] UNIV GUAM,MARINE LAB,MANGILAO,GU 96923

[4] ELI LILLY & CO,LILLY RES LABS,INDIANAPOLIS,IN 46285

[5] NCI,BETHESDA,MD 20892

来源：

INTERNATIONAL JOURNAL OF PHARMACOGNOSY | 1995年 / 33卷

关键词：

DRUG DISCOVERY; NATURAL PRODUCTS; IN VITRO ASSAY; CYANOPHYTES; SPONGES;

D O I：

10.3109/13880209509067088

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Cellular, in vitro assays have been both developed and employed by us to search for new, solid tumor specific anticancer agents. Parallel in vivo models are then used to assess the therapeutic efficacy of candidates selected by the in vitro assays. During the past 4 years, extracts as well as pure compounds from natural products have been obtained from collaborators at the University of Hawaii and Lilly Research Laboratories. The samples have been analyzed, the structures identified and a number of lead compounds proposed.

引用

页码：59 / 66

页数：8

共 7 条

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[2]

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[3]

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[6]

VALERIOTE F, 1995, IN PRESS CANCER INVE

[7]

VALERIOTE FA, 1994, DISCOVERY DEV ANTICA, P1

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