EFFECTS OF A VIGILANCE-ENHANCING DRUG, MODAFINIL, ON RAT-BRAIN METABOLISM - A 2D COSY H-1-NMR STUDY

被引：38

作者：

PIERARD, C

SATABIN, P

LAGARDE, D

BARRERE, B

GUEZENNEC, CY

MENU, JP

PERES, M

机构：

[1] Lab. RMN in vivo, Dept. de Physiologie Systémique, Institut de Médecine Aérospatiale (IMASSA-CERMA), 91223 Bretigny Sur Orge Cedex

来源：

BRAIN RESEARCH | 1995年 / 693卷 / 1-2期

关键词：

MODAFINIL; BRAIN METABOLISM; EXCITATORY AMINO ACID; INOSITOL; CREATINE-PHOSPHOCREATINE; H-1-NMR SPECTROSCOPY;

D O I：

10.1016/0006-8993(95)00711-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of modafinil, a vigilance-enhancing drug, on brain metabolism were investigated directly in situ by the 2D COSY H-1-NMR spectroscopy in anesthetized rats. Modafinil (600 mg/kg, i.p.) induced significant increases in both aspartate (72% +/- 15%) and glutamate-glutamine pool (28% +/- 8%) simultaneously with increases in inositol (51% +/- 19%) and creatine-phosphocreatine pool (47% +/- 14%) in comparison with control values (P < 0.05; n = 5). These results suggest that the awakening properties of modafinil could be mediated by metabolic activation.

引用

页码：251 / 256

页数：6

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