UNUSUAL TRANSFORMATION OF THE 3-HYDROXY-PICOLINOYL RESIDUE OF PRISTINAMYCIN I-A

被引：2

作者：

PARIS, JM ^{[1
]}

FRANCOIS, J ^{[1
]}

MOLHERAT, C ^{[1
]}

ALBANO, F ^{[1
]}

ROBIN, M ^{[1
]}

VUILHORGNE, M ^{[1
]}

BARRIERE, JC ^{[1
]}

机构：

[1] RHONE POULENC RORER SA,CTR RECH VITRY ALFORTVILLE,F-94403 VITRY,FRANCE

来源：

JOURNAL OF ANTIBIOTICS | 1995年 / 48卷 / 07期

关键词：

D O I：

10.7164/antibiotics.48.676

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Pristinamycin I-A was modified in a two-step procedure to give original derivatives possessing a tricyclic nucleus (8a, 8b, 8c) or a substituted pyrrole ring (10a, 10b) in place of the natural exocyclic 3-hydroxy-picolinoyl residue. This transformation involved firstly preparation of pyridinium betaines 5 from pristinamycin I-A and secondly a 1 similar to 3 dipolar cycloaddition between 5 and N-substituted maleimides or diethyl acetylenedicarboxylate. The compounds obtained were evaluated as antibacterial agents alone and in association with pristinamycin IIA.

引用

页码：676 / 682

页数：7

共 19 条

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