HISTAMINE H2-RECEPTOR ANTAGONISTS INHIBIT ENZYMIC HISTAMINE DEGRADATION IN HUMAN-SKIN

被引：4

作者：

CORBETT, R

GREAVES, MW

机构：

[1] Institute of Dermatology, London, E9 6BX, Homerton Grave

来源：

CLINICAL AND EXPERIMENTAL DERMATOLOGY | 1979年 / 4卷 / 01期

关键词：

D O I：

10.1111/j.1365-2230.1979.tb01596.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The histamine H2‐receptor antagonists burimamide and cimetidine cause inhibition of human skin histamine‐N‐methyl transferase (HMT) in the dose range 10‐3–10‐4 M. Amodiaquin, a recognized inhibitor of animal HMT, also produced dose‐related inhibition of human HMT. These findings may explain the observation that H2‐receptor antagonists enhance certain types of inflammatory response in skin. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：99 / 102

页数：4

共 9 条

[1] Avella J., Madsen J.E., Binder H.J., Askenase P.W., Effect of histamine H2‐receptor antagonists on delayed hypersensitivity, Lancet, 1, pp. 624-626, (1978)
[2] Barth H., Niemeyer I., Lorenz W., Similar actions of methylated histamines and histamine receptor antagonists on gastric histamine methyl transferase, Agents and Actions, 3, pp. 173-175, (1973)
[3] Francis D., Greaves M.W., Yamamoto S., Enzymatic histamine degradation by human skin, British Journal of Pharmacology, 60, pp. 583-587, (1977)
[4] Greaves M.W., H2‐receptor antagonists and delayed hypersensitivity, Lancet, 1, pp. 881-882, (1978)
[5] Marks R., Greaves M.W., Vascular reactions to histamine and compound 48/80 in human skin: suppression by a histamine H2‐receptor blocking agent, British Journal of Clinical Pharmacology, 4, pp. 367-369, (1977)
[6] Robertson I., Greaves M.W., Responses of human skin blood vessels to synthetic histamine analogues, British Journal of Clinical Pharmacology, 5, pp. 319-322, (1978)
[7] Thithapendha A., Cohn V.H., Brain histamine‐N‐methyl transferase purification, mechanism of action, and inhibition by drugs, Biochemical Pharmacology, 27, pp. 263-271, (1978)
[8] Wyllie J.H., Hesselbo T., Black J.W., Effects in man of histamine H2‐receptor blockade by burimamide, Lancet, 2, pp. 1117-1120, (1972)
[9] Yamamoto S., Francis D., Greaves M.W., Enzymic histamine metabolism in gunea pig skin and its role in immediate hypersensitivity reactions, Clinical and Experimental Immunology, 26, pp. 583-589, (1976)

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