USE OF SUBSTITUENT CONSTANTS IN QUANTITATIVE TREATMENT OF HAPTEN-ANTIBODY INTERACTION

被引：39

作者：

KUTTER, E

HANSCH, C

机构：

[1] Department of Chemistry, Pomona College, Claremont

来源：

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS | 1969年 / 135卷 / 1-2期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0003-9861(69)90523-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Regression analysis and substituent constants have been employed to analyze the roles of different intermolecular forces in hapten-antibody interaction using the experimental data of Pressman, Pauling, and their associates. From a study of benzoate and arsonate haptens with various antibodies, it was concluded that steric repulsion by substituents, as measured by the Es parameter, is the most important variable. Hydrophobic and electronic effects of substituents appear to be much less important. © 1969.

引用

页码：126 / &

共 25 条

[11] STRUCTURE-ACTIVITY RELATIONSHIP IN BARBITURATES AND ITS SIMILARITY TO THAT IN OTHER NARCOTICS [J].