LOCAL AGGREGATION OF HORMONE-RECEPTOR COMPLEXES IS REQUIRED FOR ACTIVATION BY EPIDERMAL GROWTH-FACTOR

被引：225

作者：

SCHECHTER, Y ^{[1
]}

HERNAEZ, L ^{[1
]}

SCHLESSINGER, J ^{[1
]}

CUATRECASAS, P ^{[1
]}

机构：

[1] WEIZMANN INST SCI, DEPT IMMUNOL, REHOVOT 76100, ISRAEL

来源：

NATURE | 1979年 / 278卷 / 5707期

关键词：

D O I：

10.1038/278835a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

An analogue of epidermal growth factor (EGF) which is virtually devoid of biological activity retains receptor binding activity but cannot form cell surface clusters or patches. Bivalent anti-EGF antibodies restore both bioactivity and patch formation. The sensitivity of fibroblasts to native EGF can also be enhanced greatly by these antibodies, especially in hormone-resistant cell lines. © 1979 Nature Publishing Group.

引用

页码：835 / 838

页数：4

共 25 条

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[6] MEMBRANE RECEPTORS
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[9] EPIDERMAL GROWTH-FACTOR - RECEPTORS IN HUMAN FIBROBLASTS AND MODULATION OF ACTION BY CHOLERA TOXIN
HOLLENBERG, MD
CUATRECASAS, P
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (10) : 2964 - 2968
[10] ANTIBODIES TO PURIFIED INSULIN RECEPTOR HAVE INSULIN-LIKE ACTIVITY
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CHANG, KJ
CUATRECASAS, P
[J]. SCIENCE, 1978, 200 (4347) : 1283 - 1284

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